Long-Term Natural Course of Small Nonfunctional Pancreatic Neuroendocrine Tumors in MEN1-Results From the Dutch MEN1 Study Group
| العنوان: | Long-Term Natural Course of Small Nonfunctional Pancreatic Neuroendocrine Tumors in MEN1-Results From the Dutch MEN1 Study Group |
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| المؤلفون: | Jos W. R. Twisk, Olaf M. Dekkers, Koen M.A. Dreijerink, Rachel S van Leeuwaarde, Peter H. Bisschop, Joanne M. de Laat, Madeleine L. Drent, Anouk N A van der Horst-Schrivers, Gerlof D. Valk, Menno R. Vriens, Inne H.M. Borel Rinkes, Carolina R. C. Pieterman, B. Havekes, Ad R. M. M. Hermus, Wouter W. de Herder |
| المساهمون: | Guided Treatment in Optimal Selected Cancer Patients (GUTS), Clinical Neuropsychology, IBBA, Methodology and Applied Biostatistics, Internal Medicine, CCA - Cancer Treatment and quality of life, Epidemiology and Data Science, Internal medicine, Amsterdam Neuroscience - Mood, Anxiety, Psychosis, Stress & Sleep, AGEM - Endocrinology, metabolism and nutrition, ACS - Atherosclerosis & ischemic syndromes, AGEM - Amsterdam Gastroenterology Endocrinology Metabolism, AMS - Amsterdam Movement Sciences, Endocrinology, Interne Geneeskunde, MUMC+: MA Endocrinologie (9), RS: NUTRIM - R1 - Obesity, diabetes and cardiovascular health, RS: NUTRIM - R1 - Metabolic Syndrome |
| المصدر: | Journal of Clinical Endocrinology and Metabolism, 102(10), 3795-3805 Journal of Clinical Endocrinology and Metabolism, 102(10), 3795-3805. ENDOCRINE SOC Pieterman, C R C, de Laat, J M, Twisk, J W R, van Leeuwaarde, R S, de Herder, W W, Dreijerink, K M A, Hermus, A R M M, Dekkers, O M, van der Horst-Schrivers, A N A, Drent, M L, Bisschop, P H, Havekes, B, Borel Rinkes, I H M, Vriens, M R & Valk, G D 2017, ' Long-Term Natural Course of Small Nonfunctional Pancreatic Neuroendocrine Tumors in MEN1-Results From the Dutch MEN1 Study Group ', The Journal of clinical endocrinology and metabolism, vol. 102, no. 10, pp. 3795-3805 . https://doi.org/10.1210/jc.2017-00372Test Journal of Clinical Endocrinology and Metabolism, 102(10), 3795-3805. Oxford University Press Journal of Clinical Endocrinology and Metabolism, 102(10), 3795. The Endocrine Society Journal of Clinical Endocrinology and Metabolism, 102(10), 3795-3805. Endocrine Society Journal of Clinical Endocrinology and Metabolism, 102, 10, pp. 3795-3805 The Journal of clinical endocrinology and metabolism, 102(10), 3795-3805. The Endocrine Society Journal of clinical endocrinology and metabolism, 102(10), 3795-3805. The Endocrine Society Journal of Clinical Endocrinology and Metabolism, 102, 3795-3805 Journal of Clinical Endocrinology & Metabolism, 102(10), 3795-3805. Oxford University Press Pieterman, C R C, de Laat, J M, Twisk, J W R, van Leeuwaarde, R S, de Herder, W W, Dreijerink, K M A, Hermus, A R M M, Dekkers, O M, van der Horst-Schrivers, A N A, Drent, M L, Bisschop, P H, Havekes, B, Borel Rinkes, I H M, Vriens, M R & Valk, G D 2017, ' Long-Term Natural Course of Small Nonfunctional Pancreatic Neuroendocrine Tumors in MEN1-Results From the Dutch MEN1 Study Group ', Journal of Clinical Endocrinology and Metabolism, vol. 102, no. 10, pp. 3795-3805 . https://doi.org/10.1210/jc.2017-00372Test |
| سنة النشر: | 2017 |
| مصطلحات موضوعية: | Male, Time Factors, Endocrinology, Diabetes and Metabolism, Vascular damage Radboud Institute for Health Sciences [Radboudumc 16], Clinical Biochemistry, Neuroendocrine tumors, PHENOTYPE, Biochemistry, DISEASE, PATHWAY, 0302 clinical medicine, Endocrinology, Missense mutation, Longitudinal Studies, Multiple endocrine neoplasia, ENDOCRINE NEOPLASIA TYPE-1, education.field_of_study, Middle Aged, Prognosis, Tumor Burden, Natural history, Neuroendocrine Tumors, 030220 oncology & carcinogenesis, SURVIVAL, Disease Progression, Female, HIGHER RISK, Cohort study, EXPRESSION, Adult, medicine.medical_specialty, Population, Observational Study, 030209 endocrinology & metabolism, Biology, 03 medical and health sciences, Young Adult, SDG 3 - Good Health and Well-being, Internal medicine, medicine, Journal Article, Multiple Endocrine Neoplasia Type 1, Humans, MEN1, COHORT, education, Retrospective Studies, MUTATIONS, Biochemistry (medical), Retrospective cohort study, GTE, medicine.disease, Pancreatic Neoplasms |
| الوصف: | Background: Pancreatic neuroendocrine tumors (pNETs) are highly prevalent in patients with multiple endocrine neoplasia type 1 (MEN1), and metastatic disease is an important cause of MEN1-related mortality. Especially small nonfunctional (NF) pNETs pose a challenge to the treating physician and more information is needed regarding their natural course. We assessed long-term natural history of small NF-pNETs and its modifiers in the Dutch MEN1 population.Patients and Methods: Retrospective longitudinal observational cohort study of patients with small (90% of the Dutch MEN1 population. Modifiers of long-term natural course were analyzed using linear mixed-models analysis.Results: Growth rate of the 115 included small NF-pNETs from 99 patients was slow (0.4 mm/y; 95% confidence interval, 0.15 to 0.59). Seventy percent of the tumors was stable and a subgroup of 30% of the tumors was growing (1.6 mm/y; 95% confidence interval, 1.1 to 2.0). No differences in clinical characteristics were identified between growing and stable tumors. Within the subgroup of growing tumors, germline missense mutations were significantly associated with accelerated growth compared with nonsense and frameshift mutations.Conclusion: The majority of small NF-pNETs are stable at long-term follow-up, irrespective of the underlying MEN1 genotype. A subgroup of tumors is slowly growing but cannot be identified on clinical grounds. In this subgroup, tumors with missense mutations exhibited faster growth. Additional events appear necessary for pNETs to progress. Future studies should be aimed at identifying these molecular driving events, which could be used as potential biomarkers. |
| وصف الملف: | application/pdf; image/pdf |
| تدمد: | 1945-7197 0021-972X |
| الوصول الحر: | https://explore.openaire.eu/search/publication?articleId=doi_dedup___::d06d58fa46ebfc3ea3d910a46589799fTest https://pubmed.ncbi.nlm.nih.gov/28938468Test |
| حقوق: | OPEN |
| رقم الانضمام: | edsair.doi.dedup.....d06d58fa46ebfc3ea3d910a46589799f |
| قاعدة البيانات: | OpenAIRE |
| تدمد: | 19457197 0021972X |
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