Impact of Month of Birth on the Risk of Development of Autoimmune Addison's Disease
| العنوان: | Impact of Month of Birth on the Risk of Development of Autoimmune Addison's Disease |
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| المؤلفون: | Agnieszka Pazderska, Catherine Napier, Marek Ruchala, Earn H Gan, Marta Fichna, Anna L. Mitchell, Simon H. S. Pearce, Mauro Santibanez-Koref |
| المصدر: | The Journal of Clinical Endocrinology and Metabolism |
| بيانات النشر: | Endocrine Society, 2016. |
| سنة النشر: | 2016 |
| مصطلحات موضوعية: | 0301 basic medicine, Adult, Male, Risk, medicine.medical_specialty, Adolescent, Endocrinology, Diabetes and Metabolism, Clinical Biochemistry, Population, 030209 endocrinology & metabolism, Context (language use), Disease, Biochemistry, vitamin D deficiency, Cohort Studies, 03 medical and health sciences, Young Adult, 0302 clinical medicine, Endocrinology, Addison Disease, Internal medicine, medicine, Humans, Registries, Young adult, education, Child, Aged, Aged, 80 and over, Type 1 diabetes, education.field_of_study, business.industry, Biochemistry (medical), Original Articles, Middle Aged, medicine.disease, United Kingdom, 030104 developmental biology, Cohort, Female, Poland, Seasons, business, Cohort study |
| الوصف: | Context: The pathogenesis of autoimmune Addison's disease (AAD) is thought to be due to interplay of genetic, immune, and environmental factors. A month-of-birth effect, with increased risk for those born in autumn/winter months, has been described in autoimmune conditions such as type 1 diabetes and autoimmune thyroid disease. Objective: Month-of-birth effect was investigated in 2 independent cohorts of AAD subjects. Design, Setting, and Patients: The monthly distribution of birth in AAD patients was compared with that of the general population using the cosinor test. A total of 415 AAD subjects from the United Kingdom cohort were compared with 8 180 180 United Kingdom births, and 231 AAD subjects from the Polish cohort were compared with 2 421 384 Polish births. Main Outcome Measures: Association between month of birth and the susceptibility to AAD. Results: In the entire cohort of AAD subjects, month-of-birth distribution analysis showed significant periodicity with peak of births in December and trough in May (P = .028). Analysis of the odds ratio distribution based on month of birth in 2 cohorts of patients with AAD versus the general population revealed a December peak and May trough, and January peak and July trough, in the United Kingdom and Polish cohorts, respectively. Conclusion: For the first time, we demonstrate that month of birth exerts an effect on the risk of developing AAD, with excess risk in individuals born in winter months and a protective effect when born in the summer. Exposure to seasonal viral infections in the perinatal period, coupled with vitamin D deficiency, could lead to dysregulation of innate immunity affecting the risk of developing AAD. We show for the first time that month of birth exerts an effect on the risk of developing AAD, with excess risk in individuals born in winter months and a protective effect when born in the summer. |
| اللغة: | English |
| تدمد: | 1945-7197 0021-972X |
| الوصول الحر: | https://explore.openaire.eu/search/publication?articleId=doi_dedup___::2adcea3a7d992cd887a7ad0ad3b408a1Test http://europepmc.org/articles/PMC5095257Test |
| حقوق: | OPEN |
| رقم الانضمام: | edsair.doi.dedup.....2adcea3a7d992cd887a7ad0ad3b408a1 |
| قاعدة البيانات: | OpenAIRE |
| تدمد: | 19457197 0021972X |
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