Performance of 18F-FDG PET/CT in the Characterization of Adrenal Masses in Noncancer Patients: A Prospective Study
| العنوان: | Performance of 18F-FDG PET/CT in the Characterization of Adrenal Masses in Noncancer Patients: A Prospective Study |
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| المؤلفون: | Damien Huglo, Carole Guerin, Catherine Ansquer, Cendrine Archange, Karine Baumstarck, David Taïeb, Frederic Sebag, Claire Houzard, Anderson Loundou, Pierre Olivier, Antoine Tabarin, Elif Hindié, Eric Mirallié, François Pattou, Jean-Christophe Lifante, Magalie Haissaguerre, Laurent Brunaud |
| المصدر: | The Journal of Clinical Endocrinology & Metabolism. 102:2465-2472 |
| بيانات النشر: | The Endocrine Society, 2017. |
| سنة النشر: | 2017 |
| مصطلحات موضوعية: | Male, Endocrinology, Diabetes and Metabolism, Clinical Biochemistry, Adrenal Gland Neoplasms, 030209 endocrinology & metabolism, Context (language use), Malignancy, Sensitivity and Specificity, Biochemistry, Statistics, Nonparametric, Cohort Studies, 03 medical and health sciences, 0302 clinical medicine, Endocrinology, Adrenal masses, Fluorodeoxyglucose F18, Positron Emission Tomography Computed Tomography, Adrenal Glands, Biopsy, Image Processing, Computer-Assisted, medicine, Humans, Prospective Studies, Prospective cohort study, Aged, medicine.diagnostic_test, business.industry, Biopsy, Needle, Biochemistry (medical), Washout, Middle Aged, medicine.disease, Immunohistochemistry, ROC Curve, Positron emission tomography, Area Under Curve, 030220 oncology & carcinogenesis, Population study, Female, France, Nuclear medicine, business |
| الوصف: | Few prospective studies have evaluated the role of 18F-fluorodeoxyglucose positron emission tomography/computed tomography (18F-FDG PET/CT) in the characterization of adrenal masses.To assess the performance of 18F-FDG PET/CT in the malignancy diagnosis of adrenal masses in noncancer patients.Prospective multicenter study.The study population consisted of 87 patients (87 adrenal masses) referred to endocrine surgeons: 56 with mass diameter ≥40 mm and 31 with a diameter40 mm and of indeterminate nature based on unenhanced and washout CT attenuation densities. Fourteen patients had hypercortisolism. Adrenal masses were characterized by 18F-FDG PET/CT. Histology was the gold standard for the diagnosis of malignancy. In the absence of pathological proof (n = 23), the nature of the lesion was based on the 12-month imaging follow-up.Fifteen adrenal masses were classified as malignant (including 11 adrenocortical carcinomas) and 72 as benign. Compared with benign lesions, malignant lesions were larger in size (P = 0.003), had higher unenhanced densities (P = 0.002), lower relative washout values (P = 0.007), and higher 18F-FDG uptake parameters (P10-3). The optimal threshold value of (Tumor SUVmax:Liver SUVmax) the ratio for malignancy was1.5 with sensitivity, specificity, positive predictive value, negative predictive value, and accuracy of 86.7%, 86.1%, 56.5%, 96.9%, and 86.2%, respectively.Our results show that 18F-FDG PET/CT complements adrenal washout CT in the evaluation of adrenal masses and should be recommended in the evaluation of large and/or indeterminate adrenal masses. |
| تدمد: | 1945-7197 0021-972X |
| الوصول الحر: | https://explore.openaire.eu/search/publication?articleId=doi_dedup___::7d83649bf65ac902ba28143b4d058edfTest https://doi.org/10.1210/jc.2017-00254Test |
| حقوق: | OPEN |
| رقم الانضمام: | edsair.doi.dedup.....7d83649bf65ac902ba28143b4d058edf |
| قاعدة البيانات: | OpenAIRE |
| تدمد: | 19457197 0021972X |
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