Oral rivaroxaban for the prevention of symptomatic venous thromboembolism after elective hip and knee replacement
| العنوان: | Oral rivaroxaban for the prevention of symptomatic venous thromboembolism after elective hip and knee replacement |
|---|---|
| المؤلفون: | Frank Misselwitz, Ajay K. Kakkar, Alexander G.G. Turpie, Tiemo J. Bandel, Michael Gent, Martin Homering, Michael R. Lassen, Bengt I. Eriksson |
| المصدر: | The Journal of Bone and Joint Surgery. British volume. :636-644 |
| بيانات النشر: | British Editorial Society of Bone & Joint Surgery, 2009. |
| سنة النشر: | 2009 |
| مصطلحات موضوعية: | Adult, Male, medicine.medical_specialty, Adolescent, Arthroplasty, Replacement, Hip, Morpholines, medicine.medical_treatment, Administration, Oral, Knee replacement, Thiophenes, Drug Administration Schedule, Young Adult, Double-Blind Method, Rivaroxaban, Humans, Medicine, Orthopedics and Sports Medicine, Arthroplasty, Replacement, Enoxaparin, Arthroplasty, Replacement, Knee, Aged, Aged, 80 and over, business.industry, Incidence (epidemiology), Anticoagulants, Venous Thromboembolism, Odds ratio, Middle Aged, medicine.disease, Arthroplasty, Thrombosis, Confidence interval, Surgery, Venous thrombosis, Treatment Outcome, Anesthesia, Female, business, Factor Xa Inhibitors, medicine.drug |
| الوصف: | A once-daily dose of rivaroxaban 10 mg, an oral, direct Factor Xa inhibitor, was compared with enoxaparin 40 mg subcutaneously once daily for prevention of venous thromboembolism in three studies of patients undergoing elective hip and knee replacement (RECORD programme). A pooled analysis of data from these studies (n = 9581) showed that rivaroxaban was more effective than enoxaparin in reducing the incidence of the composite of symptomatic venous thromboembolism and all-cause mortality at two weeks (0.4% vs 0.8%, respectively, odds ratio 0.44; 95% confidence interval 0.23 to 0.79; p = 0.005), and at the end of the planned medication period (0.5% vs 1.3%, respectively; odds ratio 0.38; 95% confidence interval 0.22 to 0.62; p < 0.001). The rate of major bleeding was similar at two weeks (0.2% for both) and at the end of the planned medication period (0.3% vs 0.2%). Rivaroxaban started six to eight hours after surgery was more effective than enoxaparin started the previous evening in preventing symptomatic venous thromboembolism and all-cause mortality, without increasing major bleeding. |
| تدمد: | 2044-5377 0301-620X |
| الوصول الحر: | https://explore.openaire.eu/search/publication?articleId=doi_dedup___::2512fd2453e0be3d46331ef308401ad2Test https://doi.org/10.1302/0301-620x.91b5.21691Test |
| حقوق: | OPEN |
| رقم الانضمام: | edsair.doi.dedup.....2512fd2453e0be3d46331ef308401ad2 |
| قاعدة البيانات: | OpenAIRE |
| تدمد: | 20445377 0301620X |
|---|