نتائج البحث - "Lactate dehydrogenase"

1

دورية أكاديمية

Effects of grape seed-derived polyphenols on amyloid beta-protein self-assembly and cytotoxicity.

المؤلفون: Ono, Kenjiro, Condron, Margaret M, Ho, Lap, Wang, Jun, Zhao, Wei, Pasinetti, Giulio M, Teplow, David B

المصدر: The Journal of biological chemistry. 283(47)

وصف الملف: application/pdf

الوصول الحر: https://escholarship.org/uc/item/3zq7983kTest

View record in eScholarship

2

Signaling metabolite L-2-hydroxyglutarate activates the transcription factor HIF-1α in lipopolysaccharide-activated macrophages

المؤلفون: Niamh C. Williams, Dylan G. Ryan, Ana S.H. Costa, Evanna L. Mills, Mark P. Jedrychowski, Suzanne M. Cloonan, Christian Frezza, Luke A. O'Neill

المصدر: The Journal of Biological Chemistry

مصطلحات موضوعية: Lipopolysaccharides, αKG, α-ketoglutarate, 2HGDH, 2-hydroxyglutarate dehydrogenase, immunometabolism, OXPHOS, oxidative phosphorylation, IDH, isocitrate dehydrogenase, L-2-hydroxyglutarate, macrophage, Biochemistry, Glutarates, 03 medical and health sciences, IL-1β, interleukin 1β, 0302 clinical medicine, TET, ten-eleven translocation DNA hydroxylase, Humans, 2HG, 2-hydroxyglutarate, Molecular Biology, KDM, Jmjj-domain containing histone lysine demethylases, 030304 developmental biology, 0303 health sciences, LDH, lactate dehydrogenase, Macrophages, PHD, HIF prolyl hydroxylase, Cell Biology, MDH, malate dehydrogenase, Macrophage Activation, glycolysis, Hypoxia-Inducible Factor 1, alpha Subunit, interleukin 1β (IL-1β), hypoxia-inducible factor (HIF), BMDM, bone-marrow-derived macrophages, mtROS, mitochondrial reactive oxygen species, HEK293 Cells, inflammation, 030220 oncology & carcinogenesis, SDH, succinate dehydrogenase, HIF-1α, hypoxia-inducible factor 1α, LPS, lipopolysaccharide, Research Article

الوصول الحر: https://explore.openaire.eu/search/publication?articleId=doi_dedup___::349c95bf1633c1057ab765daa0319a9aTest
https://pubmed.ncbi.nlm.nih.gov/34929172Test

3

Hypoxia inhibits colonic uptake of the microbiota-generated forms of vitamin B1 via HIF-1α-mediated transcriptional regulation of their transporters

المؤلفون: Sabui, Subrata, Ramamoorthy, Kalidas, Romero, Jose M, Simoes, Rita D, Fleckenstein, James M, Said, Hamid M

المصدر: The Journal of Biological Chemistry
The Journal of biological chemistry, vol 298, iss 2

مصطلحات موضوعية: Biochemistry & Molecular Biology, 1.1 Normal biological development and functioning, HRE, hypoxia-responsive element, NF-1, neurofibromatosis-1, HIF-1α, TPP, thiamin pyrophosphate, alpha Subunit, Medical and Health Sciences, Biochemistry, THTR-1, thiamin transporter-1, human differentiated colonoid monolayers, Underpinning research, Genetics, Humans, LDHA, lactate dehydrogenase A, Thiamine, CREB, cAMP responsive element–binding protein, Hypoxia, Molecular Biology, Nutrition, Elf-3, E74-like ETS transcription factor 3, GKLF-4, gut-enriched Krüppel-like factor 4, IBD, inflammatory bowel disease, hypoxia, Microbiota, Membrane Transport Proteins, Biological Transport, THTR-2, thiamin transporter-2, Cell Biology, Biological Sciences, Hypoxia-Inducible Factor 1, alpha Subunit, Cell Hypoxia, HIF, hypoxia-inducible transcription factor, PGK-1, phosphoglycerate kinase 1, Chemical Sciences, vitamin B1 uptake, cTPPT, colonic TPP transporter, DFO, desferrioxamine, Hypoxia-Inducible Factor 1, Thiamine Pyrophosphate, qPCR, quantitative PCR, SP-1, specificity protein 1, Research Article

وصف الملف: application/pdf

الوصول الحر: https://explore.openaire.eu/search/publication?articleId=doi_dedup___::97ff343a85a7aede113b010d241e7a88Test
https://pubmed.ncbi.nlm.nih.gov/34998824Test

4

The nuclear receptor RORα preserves cardiomyocyte mitochondrial function by regulating caveolin-3-mediated mitophagy

المؤلفون: Hong Soon Kang, Anton M. Jetten, Kevin Gerrish, Amir Aghajanian, Ju Youn Beak, Brian C. Jensen, Seok Jae Hong, Wei Huang, Rishi Deshmukh, Nishi Kadakia

المصدر: The Journal of Biological Chemistry

مصطلحات موضوعية: HIF-1α, hypoxia-inducible factor-1α, Caveolin 3, PINK1, PTEN-induced putative kinase 1, LC3B-II, microtubule-associated protein light chain beta 3-II, Mitochondrion, Biochemistry, CMKO, cardiomyocyte-specific RORα KO, JC-1, 5, 5′, 6, 6′-tetrachloro-1, 1′, 3, 3′-tetraethylbenzimidazolylcarbocyanine iodide, Mitochondria, Heart, Mice, Mitophagy, OCR, oxygen consumption rate, Myocytes, Cardiac, Cav-3, caveolin-3, mt-Keima, mitochondrial-targeted Keima, shCtrl, scrambled shRNA, Cardioprotection, Gene knockdown, LDH, lactate dehydrogenase, Bnip3, BCL2 interacting protein 3, HRP, horseradish peroxidase, Nuclear Receptor Subfamily 1, Group F, Member 1, shRORα, shRNA against RORα, Cell biology, ChIP, chromatin immunoprecipitation, BFA1, bafilomycin A1, SDH, succinate dehydrogenase, NRVMs, neonatal rat ventricular myocytes, qRT-PCR, quantitative RT-PCR, Research Article, caveolin-3, mPTP, mitochondrial permeability transition pore, cardiomyocyte mitochondrial physiology, Biology, ROS, reactive oxygen species, Downregulation and upregulation, Animals, TEM, transmission electron microscopy, Molecular Biology, ROR, retinoic acid–related orphan nuclear receptor, Ang II, angiotensin II, hypoxia, Autophagy, Cell Biology, RAR-related orphan receptor alpha (ROR-alpha), Nuclear receptor, Hsp60, heat shock protein 60, PFA, paraformaldehyde

الوصول الحر: https://explore.openaire.eu/search/publication?articleId=doi_dedup___::47cc243bde3123b1ebf3e9dc15c170f2Test
http://europepmc.org/articles/PMC8626585Test

5

Catalytic and structural insights into a stereospecific and thermostable Class II aldolase HpaI from Acinetobacter baumannii

المؤلفون: Pimchai Chaiyen, Jirawat Tantipisit, Asweena Binlaeh, Litavadee Chuaboon, Juthamas Jaroensuk, Somchart Maenpuen, Penchit Chitnumsub, Ruchanok Tinikul, Aritsara Jaruwat, Jittima Phonbuppha, Pratchaya Watthaisong, Narin Lawan

المصدر: The Journal of Biological Chemistry

مصطلحات موضوعية: structure–function, p-hydroxyphenylacetate degradation pathway, Acinetobacter baumannii, Enzyme complex, PMSF, phenyl methane sulfonyl fluoride, QM/MM, quantum mechanics/molecular mechanics, DHAP, dihydroxyacetone phosphate, SSA, succinic semialdehyde, Crystallography, X-Ray, Biochemistry, HKHD, 4-hydroxy-2-ketoheptane-1,7-dioate, MW, molecular weight, Substrate Specificity, FPLC, fast protein liquid chromatography, LC-ESI-QTOF-MS, liquid chromatography-electrospray ionization-quadrupole-time-of-flight mass spectrometer, NaCl, sodium chloride, Aldol reaction, stereospecificity, Catalytic Domain, Fructose-Bisphosphate Aldolase, Enzyme Stability, Tm, melting temperature, PPA, propionaldehyde, biology, solvent-tolerant enzyme, LDH, lactate dehydrogenase, Chemistry, MD, molecular dynamics, Enzyme structure, HOPA, 4-hydroxy-2-oxopentanoate, Zinc, (NH4)2SO4, ammonium sulfate, PYR, pyruvate, metal-dependent enzyme, Research Article, crystal structure, HNO3, nitric acid, SEC, size-exclusion chromatography, ICP-OES, inductively coupled plasma-optical emission spectrometry, Stereochemistry, (4R)-KDGal, (4R)-2-keto-3-deoxy-D-galactonate, stereoselectivity, enzyme catalysis, Catalysis, Enzyme catalysis, Stereospecificity, (4S)-KDGlu, (4S)-2-keto-3-deoxy-D-gluconate, Bacterial Proteins, PDB, Protein Data Bank, NADH, the reduced β-nicotinamide adenine dinucleotide, thermostable enzyme, Molecular Biology, M2+, divalent meatl ion, PEI, polyethyleneimine, MPD, 2-methyl-2,4-pentanediol, Aldolase A, EGTA, ethylene glycol-bis(2-aminoethylether)-N,N,N′,N′-tetraacetic acid, HEPES, 4-(2-hydroxyethyl)-1-piperazineethanesulfonic acid, Cell Biology, AbHpaI, 4-hydroxy-2-ketoheptane-1,7-dioate aldolase from Acinetobacter baumannii, HBA, 4-hydroxybenzaldehyde, EcHpaI, 4-hydroxy-2-ketoheptane-1,7-dioate aldolase from Escherichia coli, Biocatalysis, DTT, dithiothreitol, biology.protein, Aldol condensation, BSA, bovine serum albumin, EDTA, ethylenediaminetetraacetatic acid, Calcium, OAA, oxaloacetate, pyruvate-specific Class II metal aldolase

الوصول الحر: https://explore.openaire.eu/search/publication?articleId=doi_dedup___::69ec40387511a3835e3f518a5fda0050Test
http://europepmc.org/articles/PMC8560999Test

6

Sequence determinants in the cathelicidin LL-37 that promote inflammation via presentation of RNA to scavenger receptors

المؤلفون: Richard L. Gallo, Tatsuya Dokoshi, Alan M. O’Neill, Elizabeth Wei Chia Luo, Nikhil Nitin Kulkarni, Gerard C. L. Wong

المصدر: The Journal of Biological Chemistry
The Journal of biological chemistry, vol 297, iss 1

مصطلحات موضوعية: 0301 basic medicine, Transcription, Genetic, medicine.medical_treatment, Inbred C57BL, Biochemistry, Medical and Health Sciences, Cathelicidin, Mice, Double-Stranded, antimicrobial peptides, SR, scavenger receptor, Receptors, cathelicidin, Innate, Receptor, GAS, group A Streptococcus, Receptors, Scavenger, Alanine, LDH, lactate dehydrogenase, Chemistry, LL-37, 37-amino acid peptide, UCSD, University of California, San Diego, SAXS, small-angle X-ray scattering, interferon, Alanine scanning, Biological Sciences, Cell biology, IL-6, interleukin 6, Infectious Diseases, LL-34, 34-amino acid peptide, Interferon Type I, qRT-PCR, quantitative RT-PCR, Female, NHEK, normal human epidermal keratinocyte, Transcription, RIGI, retinoic acid–inducible gene I, Research Article, Protein Binding, Signal Transduction, Biochemistry & Molecular Biology, skin, HDMEC, human dermal microvascular endothelial cell, MIC, minimum inhibitory concentration, Antimicrobial peptides, I20P, proline at isoleucine position 20, IRF7, interferon regulatory factor 7, Biophysical Phenomena, Scavenger, MAVS, mitochondrial antiviral signaling, Cell Line, 03 medical and health sciences, Structure-Activity Relationship, Genetic, Cathelicidins, GO, Gene Ontology, medicine, Genetics, Animals, Humans, Amino Acid Sequence, Molecular Biology, RNA, Double-Stranded, Inflammation, Innate immune system, 030102 biochemistry & molecular biology, Cell Membrane, Immunity, RNA, Cell Biology, cytokines, Immunity, Innate, Toll-Like Receptor 3, Mice, Inbred C57BL, 030104 developmental biology, Emerging Infectious Diseases, Gene Expression Regulation, Chemical Sciences, TBK1, TANK-binding kinase 1, Mutation, Nucleic acid, Antimicrobial Cationic Peptides

وصف الملف: application/pdf

الوصول الحر: https://explore.openaire.eu/search/publication?articleId=doi_dedup___::7653124affc7f3c4f58a75aed7ae4eb7Test
http://europepmc.org/articles/PMC8214221Test

7

Perm1 promotes cardiomyocyte mitochondrial biogenesis and protects against hypoxia/reoxygenation-induced damage in mice

المؤلفون: Yoshitake Cho, Anne N. Murphy, Alex Liang, Shamim Khosrowjerdi, Oliver R. Zhang, Robert S. Ross, Aleksander Andreyev, Kayla Lam, Ruixia Li, Shizuko Tachibana, Yoh Arita

المصدر: The Journal of Biological Chemistry
The Journal of biological chemistry, vol 297, iss 1

مصطلحات موضوعية: 0301 basic medicine, mitochondrial biogenesis, ATP5B, Messenger, NCM, neonatal cardiomyocytes, Muscle Proteins, cardiomyocytes, Mitochondrion, PGC-1, PPARgamma coactivator 1, SDHb, succinate dehydrogenase complex iron–sulfur subunit B, Inbred C57BL, Cardiovascular, Biochemistry, Medical and Health Sciences, OxPhos, oxidative phosphorylation, Oxidative Phosphorylation, Mice, Cox, cytochrome c oxidase, oxidative metabolism, Receptors, Myocyte, Protein Isoforms, 2.1 Biological and endogenous factors, OCR, oxygen consumption rate, Perm1, peroxisome proliferator-activated receptor coactivator 1 (PGC-1)- and estrogen-related receptor (ERR)-induced regulator, muscle 1, Aetiology, Organelle Biogenesis, Heart development, LDH, lactate dehydrogenase, Intracellular Signaling Peptides and Proteins, Heart, Biological Sciences, Cell Hypoxia, Cell biology, Mitochondria, Mitochondrial, Heart Disease, 5.1 Pharmaceuticals, medicine.symptom, Development of treatments and therapeutic interventions, Mito, mitochondrial, Cardiac, Transcription, Oxidation-Reduction, Perm1, NDUFS3, NADH dehydrogenase [ubiquinone] iron–sulfur protein 3, Research Article, Programmed cell death, Biochemistry & Molecular Biology, Heart Ventricles, Down-Regulation, ATP5b, ATP synthase F1 subunit beta, Biology, TUNEL, terminal deoxynucleotidyl transferase dUTP nick end labeling, Promoter Regions, 03 medical and health sciences, H/R, hypoxia-reoxygenation, UQCRC2, ubiquinol-cytochrome C reductase core protein 2, Genetic, Coactivator, medicine, Genetics, COXIV, cytochrome c oxidase subunit IV, Animals, Humans, Molecular Biology, Heart Failure, Myocytes, 030102 biochemistry & molecular biology, Cell Biology, DNA, Hypoxia (medical), Estrogen, Oxygen, ERR, estrogen-related receptor, 030104 developmental biology, Mitochondrial biogenesis, SERCA, Sarco/endoplasmic reticulum Ca2+-ATPase, Protein Biosynthesis, Musculoskeletal, Chemical Sciences, RNA, Transcription Factors

وصف الملف: application/pdf

الوصول الحر: https://explore.openaire.eu/search/publication?articleId=doi_dedup___::352ef9a79b8dfcd8924d67bb08dbe283Test
http://europepmc.org/articles/PMC8214196Test

8

Apolipoproteins L1-6 share key cation channel-regulating residues but have different membrane insertion and ion conductance properties

المؤلفون: Darwin Peña, Russell Thomson, Jayne Raper, Joseph A Giovinazzo, Jyoti Pant, Lilit S. Tuka

المصدر: The Journal of Biological Chemistry

مصطلحات موضوعية: PLR, pore-lining region, kidney disease, Lipid Bilayers, HDL, high-density lipoprotein, MID, membrane-insertion domain, Biochemistry, law.invention, voltage-dependent ion channel, law, apolipoprotein L, Gene family, APOL protein family, APOL gene family, Molecular Biology, innate immunity, Ion channel, Innate immune system, LDH, lactate dehydrogenase, Effector, Chemistry, IRG, interferon regulated gene, Bilayer, Cell Membrane, ion channels, Cell Biology, Editors' Pick, Apolipoprotein L1, Immunity, Innate, HIV, human immunodeficiency virus, Membrane, cell death, Apolipoproteins L, pH-gating, Biophysics, Recombinant DNA, APOL, apolipoprotein L, TLF, trypanosome lytic factor, Research Article

الوصول الحر: https://explore.openaire.eu/search/publication?articleId=doi_dedup___::d88d0d85e425f86b2edf615f0998c9b8Test
https://pubmed.ncbi.nlm.nih.gov/34252458Test

9

Multiple copies of a novel amphipathic α-helix forming segment in Physcomitrella patens dehydrin play a key role in abiotic stress mitigation

المؤلفون: Chandrima Chakraborty, Chandra Basak, Chandradeep Basu, Arup Das, Tanushree Agarwal, Sudipta Ray, Gouranga Upadhyaya, Gautam Basu, Tanmoy Halder

المصدر: The Journal of Biological Chemistry

مصطلحات موضوعية: 0301 basic medicine, Protein Conformation, alpha-Helical, nuclear magnetic resonance (NMR), BiFC, bimolecular fluorescence complementation, IDP, intrinsically disordered protein, PpDHNA, Physcomitrella patens dehydrin, Protein aggregation, cell survivability, Physcomitrella patens, Biochemistry, NT, nontransformed, dehydrin–dehydrin interaction, protein aggregation, 03 medical and health sciences, Bimolecular fluorescence complementation, Stress, Physiological, Amphiphile, VT, vector transformed, D-segment, Molecular Biology, amphipathic α-helix, Plant Proteins, TFE, trifluoroethanol, Abiotic component, high-temperature stress, MDA, malondialdehyde, 030102 biochemistry & molecular biology, biology, DHN, dehydrin, LDH, lactate dehydrogenase, Chemistry, Abiotic stress, LEA, late embryogenesis abundant, food and beverages, Cell Biology, biology.organism_classification, intrinsically disordered protein, Bryopsida, Cell biology, 030104 developmental biology, Helix, Desiccation, poikilohydric plant, Research Article, self-association

الوصول الحر: https://explore.openaire.eu/search/publication?articleId=doi_dedup___::27702aa2d0f624f6730bd6dcde5aa1ebTest
https://pubmed.ncbi.nlm.nih.gov/33781743Test

10

Determining the quantitative relationship between glycolysis and GAPDH in cancer cells exhibiting the Warburg effect

المؤلفون: Chengmeng Jin, Qiangrong Pan, Xun Hu, Xiaobing Zhu

المصدر: The Journal of Biological Chemistry

مصطلحات موضوعية: 0301 basic medicine, F6P, fructose 6-phosphate, DHAP, dihydroxyacetone phosphate, Biochemistry, NC, negative control, chemistry.chemical_compound, cell metabolism, Neoplasms, Warburg Effect, Oncologic, RNA, Small Interfering, Phosphoglycerate kinase 1, Glyceraldehyde 3-phosphate dehydrogenase, PGAM, phosphoglycerate mutase, education.field_of_study, biology, GAPDH-SA, GAPDH specific activity, LDH, lactate dehydrogenase, GAPDH, Glyceraldehyde-3-Phosphate Dehydrogenases, glycolysis, Glc, glucose, Warburg effect, TPI, triose phosphate isomerase, GA3P, glyceraldehyde 3-phosphate, flux control, Gibbs free energy, Oxidation-Reduction, Research Article, FBP, fructose 1,6-bisphosphate, G6P, glucose 6-phosphate, 03 medical and health sciences, stomatognathic system, FBS, fetal bovine serum, G6PDH, glucose-6-phosphate dehydrogenase, Cell Line, Tumor, PGI, phosphohexose isomerase, PGK, phosphoglycerate kinase, Humans, IA, iodoacetate, education, Molecular Biology, GAPDH-AA, GAPDH actual activity, Dihydroxyacetone phosphate, UPLC, ultra performance liquid chromatography, Hexokinase, 030102 biochemistry & molecular biology, PEP, phosphoenolpyruvate, Cell Biology, HK, hexokinase, Pyr, pyruvate, 030104 developmental biology, Glucose, chemistry, Glucose 6-phosphate, Anaerobic glycolysis, PK, pyruvate kinase, biology.protein, cancer cells, WE, Warburg effect, Glyceraldehyde-3-Phosphate Dehydrogenase (Phosphorylating), Pyruvate kinase

الوصول الحر: https://explore.openaire.eu/search/publication?articleId=doi_dedup___::d332adf7ec310c14c988541e3e3aa008Test
https://pubmed.ncbi.nlm.nih.gov/33545174Test

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