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المؤلفون: Hong Soon Kang, Anton M. Jetten, Kevin Gerrish, Amir Aghajanian, Ju Youn Beak, Brian C. Jensen, Seok Jae Hong, Wei Huang, Rishi Deshmukh, Nishi Kadakia
المصدر: The Journal of Biological Chemistry
مصطلحات موضوعية: HIF-1α, hypoxia-inducible factor-1α, Caveolin 3, PINK1, PTEN-induced putative kinase 1, LC3B-II, microtubule-associated protein light chain beta 3-II, Mitochondrion, Biochemistry, CMKO, cardiomyocyte-specific RORα KO, JC-1, 5, 5′, 6, 6′-tetrachloro-1, 1′, 3, 3′-tetraethylbenzimidazolylcarbocyanine iodide, Mitochondria, Heart, Mice, Mitophagy, OCR, oxygen consumption rate, Myocytes, Cardiac, Cav-3, caveolin-3, mt-Keima, mitochondrial-targeted Keima, shCtrl, scrambled shRNA, Cardioprotection, Gene knockdown, LDH, lactate dehydrogenase, Bnip3, BCL2 interacting protein 3, HRP, horseradish peroxidase, Nuclear Receptor Subfamily 1, Group F, Member 1, shRORα, shRNA against RORα, Cell biology, ChIP, chromatin immunoprecipitation, BFA1, bafilomycin A1, SDH, succinate dehydrogenase, NRVMs, neonatal rat ventricular myocytes, qRT-PCR, quantitative RT-PCR, Research Article, caveolin-3, mPTP, mitochondrial permeability transition pore, cardiomyocyte mitochondrial physiology, Biology, ROS, reactive oxygen species, Downregulation and upregulation, Animals, TEM, transmission electron microscopy, Molecular Biology, ROR, retinoic acid–related orphan nuclear receptor, Ang II, angiotensin II, hypoxia, Autophagy, Cell Biology, RAR-related orphan receptor alpha (ROR-alpha), Nuclear receptor, Hsp60, heat shock protein 60, PFA, paraformaldehyde
الوصول الحر: https://explore.openaire.eu/search/publication?articleId=doi_dedup___::47cc243bde3123b1ebf3e9dc15c170f2Test
http://europepmc.org/articles/PMC8626585Test -
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المؤلفون: Richard L. Gallo, Tatsuya Dokoshi, Alan M. O’Neill, Elizabeth Wei Chia Luo, Nikhil Nitin Kulkarni, Gerard C. L. Wong
المصدر: The Journal of Biological Chemistry
The Journal of biological chemistry, vol 297, iss 1مصطلحات موضوعية: 0301 basic medicine, Transcription, Genetic, medicine.medical_treatment, Inbred C57BL, Biochemistry, Medical and Health Sciences, Cathelicidin, Mice, Double-Stranded, antimicrobial peptides, SR, scavenger receptor, Receptors, cathelicidin, Innate, Receptor, GAS, group A Streptococcus, Receptors, Scavenger, Alanine, LDH, lactate dehydrogenase, Chemistry, LL-37, 37-amino acid peptide, UCSD, University of California, San Diego, SAXS, small-angle X-ray scattering, interferon, Alanine scanning, Biological Sciences, Cell biology, IL-6, interleukin 6, Infectious Diseases, LL-34, 34-amino acid peptide, Interferon Type I, qRT-PCR, quantitative RT-PCR, Female, NHEK, normal human epidermal keratinocyte, Transcription, RIGI, retinoic acid–inducible gene I, Research Article, Protein Binding, Signal Transduction, Biochemistry & Molecular Biology, skin, HDMEC, human dermal microvascular endothelial cell, MIC, minimum inhibitory concentration, Antimicrobial peptides, I20P, proline at isoleucine position 20, IRF7, interferon regulatory factor 7, Biophysical Phenomena, Scavenger, MAVS, mitochondrial antiviral signaling, Cell Line, 03 medical and health sciences, Structure-Activity Relationship, Genetic, Cathelicidins, GO, Gene Ontology, medicine, Genetics, Animals, Humans, Amino Acid Sequence, Molecular Biology, RNA, Double-Stranded, Inflammation, Innate immune system, 030102 biochemistry & molecular biology, Cell Membrane, Immunity, RNA, Cell Biology, cytokines, Immunity, Innate, Toll-Like Receptor 3, Mice, Inbred C57BL, 030104 developmental biology, Emerging Infectious Diseases, Gene Expression Regulation, Chemical Sciences, TBK1, TANK-binding kinase 1, Mutation, Nucleic acid, Antimicrobial Cationic Peptides
وصف الملف: application/pdf
الوصول الحر: https://explore.openaire.eu/search/publication?articleId=doi_dedup___::7653124affc7f3c4f58a75aed7ae4eb7Test
http://europepmc.org/articles/PMC8214221Test -
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المؤلفون: Yoshitake Cho, Anne N. Murphy, Alex Liang, Shamim Khosrowjerdi, Oliver R. Zhang, Robert S. Ross, Aleksander Andreyev, Kayla Lam, Ruixia Li, Shizuko Tachibana, Yoh Arita
المصدر: The Journal of Biological Chemistry
The Journal of biological chemistry, vol 297, iss 1مصطلحات موضوعية: 0301 basic medicine, mitochondrial biogenesis, ATP5B, Messenger, NCM, neonatal cardiomyocytes, Muscle Proteins, cardiomyocytes, Mitochondrion, PGC-1, PPARgamma coactivator 1, SDHb, succinate dehydrogenase complex iron–sulfur subunit B, Inbred C57BL, Cardiovascular, Biochemistry, Medical and Health Sciences, OxPhos, oxidative phosphorylation, Oxidative Phosphorylation, Mice, Cox, cytochrome c oxidase, oxidative metabolism, Receptors, Myocyte, Protein Isoforms, 2.1 Biological and endogenous factors, OCR, oxygen consumption rate, Perm1, peroxisome proliferator-activated receptor coactivator 1 (PGC-1)- and estrogen-related receptor (ERR)-induced regulator, muscle 1, Aetiology, Organelle Biogenesis, Heart development, LDH, lactate dehydrogenase, Intracellular Signaling Peptides and Proteins, Heart, Biological Sciences, Cell Hypoxia, Cell biology, Mitochondria, Mitochondrial, Heart Disease, 5.1 Pharmaceuticals, medicine.symptom, Development of treatments and therapeutic interventions, Mito, mitochondrial, Cardiac, Transcription, Oxidation-Reduction, Perm1, NDUFS3, NADH dehydrogenase [ubiquinone] iron–sulfur protein 3, Research Article, Programmed cell death, Biochemistry & Molecular Biology, Heart Ventricles, Down-Regulation, ATP5b, ATP synthase F1 subunit beta, Biology, TUNEL, terminal deoxynucleotidyl transferase dUTP nick end labeling, Promoter Regions, 03 medical and health sciences, H/R, hypoxia-reoxygenation, UQCRC2, ubiquinol-cytochrome C reductase core protein 2, Genetic, Coactivator, medicine, Genetics, COXIV, cytochrome c oxidase subunit IV, Animals, Humans, Molecular Biology, Heart Failure, Myocytes, 030102 biochemistry & molecular biology, Cell Biology, DNA, Hypoxia (medical), Estrogen, Oxygen, ERR, estrogen-related receptor, 030104 developmental biology, Mitochondrial biogenesis, SERCA, Sarco/endoplasmic reticulum Ca2+-ATPase, Protein Biosynthesis, Musculoskeletal, Chemical Sciences, RNA, Transcription Factors
وصف الملف: application/pdf
الوصول الحر: https://explore.openaire.eu/search/publication?articleId=doi_dedup___::352ef9a79b8dfcd8924d67bb08dbe283Test
http://europepmc.org/articles/PMC8214196Test -
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المؤلفون: Yan Wang, Yalin Wu, Zuguo Liu, Jingmeng Chen, Chao Chen
المصدر: The Journal of Biological Chemistry
مصطلحات موضوعية: 0301 basic medicine, Retinal degeneration, STEAP3, six-transmembrane epithelial antigen of prostate 3, genetic structures, STGD1, autosomal recessive Stargardt disease, TFRC, transferrin receptor, ONL, outer nuclear layer, Mitochondrion, medicine.disease_cause, Biochemistry, Photoreceptor cell, Mice, DMT1, Divalent metal transporter 1, GSH, glutathione, Stargardt Disease, oxidative stress, iron metabolism, AMD, age-related macular degeneration, IREB2, Iron-responsive element binding protein 2, POS, photoreceptor outer segments, chemistry.chemical_classification, Deferoxamine mesylate, LDH, lactate dehydrogenase, Chemistry, TEM, transmission electron microscope, lipid peroxidation, LED, light emitting diode, Cell biology, medicine.anatomical_structure, cell death, Retinaldehyde, Photoreceptor Cells, Vertebrate, Research Article, Programmed cell death, macular degeneration, 03 medical and health sciences, ROS, reactive oxygen species, medicine, Animals, Ferroptosis, Molecular Biology, Reactive oxygen species, Retina, 030102 biochemistry & molecular biology, Cell Biology, medicine.disease, all-trans-retinal, photoreceptor, eye diseases, TF, transferrin, Mice, Inbred C57BL, 030104 developmental biology, CP, ceruloplasmin, atRAL, all-trans-retinal, H&E, hematoxylin and eosin, sense organs, FPN, Ferroportin, Reactive Oxygen Species, Oxidative stress
الوصول الحر: https://explore.openaire.eu/search/publication?articleId=doi_dedup___::e528672cccb4554ebf9c4e807e79212aTest
https://pubmed.ncbi.nlm.nih.gov/33334878Test