نتائج البحث - "heat-shock protein"

1

دورية أكاديمية

Calcium binding to a remote site can replace magnesium as cofactor for mitochondrial Hsp90 (TRAP1) ATPase activity.

المؤلفون: Elnatan, Daniel, Agard, David A

المصدر: The Journal of biological chemistry. 293(35)

وصف الملف: application/pdf

الوصول الحر: https://escholarship.org/uc/item/3tg431n0Test

View record in eScholarship

2

Single-molecule fluorescence-based approach reveals novel mechanistic insights into human small heat shock protein chaperone function

المؤلفون: Caitlin L. Johnston, Antoine M. van Oijen, Justin L. P. Benesch, Heath Ecroyd, Nicholas R. Marzano, Bishnu P. Paudel, George G. Wright

المصدر: The Journal of Biological Chemistry

مصطلحات موضوعية: 0301 basic medicine, Protein Folding, SOD1, superoxide dismutase 1, Gene Expression, Protein aggregation, Biochemistry, Is-mean, mean intensity of a single photobleaching event, TIRF, total internal reflection fluorescence, Fluorescence Resonance Energy Transfer, Cloning, Molecular, biology, Chemistry, OSS, oxygen scavenger system, FPP, fluorescently-labeled proteins per point, CLIC1, chloride intracellular channel 1, Single-molecule FRET, molecular chaperone, Carbocyanines, Single-molecule experiment, Recombinant Proteins, Single Molecule Imaging, Solutions, I0, initial fluorescence intensity, Protein folding, αBc, αB-crystallin, Intracellular, sHsp, small heat shock protein, Research Article, proteostasis, protein homeostasis, Protein Binding, Genetic Vectors, chloride intracellular channel 1, total internal reflection fluorescence microscopy, Is, fluorescent intensity of each single-photobleaching event, protein aggregation, 03 medical and health sciences, Chloride Channels, Heat shock protein, mass photometry, GST, glutathione-S-transferase, Escherichia coli, Humans, oligomers, Molecular Biology, Fluorescent Dyes, smFRET, single-molecule FRET, protein complexes, Binding Sites, 030102 biochemistry & molecular biology, Staining and Labeling, Rhodamines, alpha-Crystallin B Chain, Cell Biology, alphaB-crystallin, 030104 developmental biology, Proteostasis, Chaperone (protein), biology.protein, Biophysics, Sulfonic Acids

الوصول الحر: https://explore.openaire.eu/search/publication?articleId=doi_dedup___::02bec87c97ef79ebe4f5a299aa15f4d4Test
http://europepmc.org/articles/PMC7921601Test

3

Using biochemistry and biophysics to extinguish androgen receptor signaling in prostate cancer

المؤلفون: Trevor M. Penning, Gregory D. Van Duyne, Irfan A. Asangani, A. Joshua Wand, Vincent J. Hilser, Ian A. Blair, Vera Y. Moiseenkova-Bell, Cynthia C. Sprenger, Stephen R. Plymate

المصدر: The Journal of Biological Chemistry

مصطلحات موضوعية: Male, 0301 basic medicine, Biochemistry, aldo-keto reductase, LBD, ligand-binding domain, T, testosterone, androgen receptor, SHR, steroid hormone receptor, mass spectrometry, allostery, splice variants, Drug discovery, Chemistry, AKR1C3, aldo-keto reductase 1C3, EAM, ensemble allosteric model, SILAC, stable isotope labeling of amino acids in cell culture, Chromatin, Cell biology, Prostatic Neoplasms, Castration-Resistant, Receptors, Androgen, HSP, heat shock protein, IHC, immunohistochemistry, Signal Transduction, Biochemical Phenomena, Steroid hormone receptor, PPI, protein–protein interaction, Allosteric regulation, Reviews, cryo-electron microscopy, FBDD, fragment-based drug discovery, Biophysical Phenomena, SID-IP-LC-MS, stable isotope dilution–immunoprecipitation–liquid chromatography–mass spectrometry, 03 medical and health sciences, proteomics, PSA, prostatic-specific antigen, NR, nuclear receptors, NTD, N-terminal transactivation domain, Coactivator, AF, activation function, Humans, ADT, androgen deprivation therapy, Molecular Biology, 030102 biochemistry & molecular biology, Cell Biology, DNA-binding domain, RISH, rapid in situ hybridization, CTC, circulating tumor cells, DHT, 5α-dihydrotestosterone, Androgen receptor, qrtPCR, quantitative real-time polymerase chain reaction, nuclear magnetic resonance, 030104 developmental biology, ARSI, androgen receptor signaling inhibitor, Nuclear receptor, DBD, DNA-binding domain, RM, reverse micelle, AR, androgen receptor, CDK7, cyclin dependent kinase 7, CAK, CDK-activating kinase

الوصول الحر: https://explore.openaire.eu/search/publication?articleId=doi_dedup___::604026f0eb231823b774b11f3348def9Test
http://europepmc.org/articles/PMC7949100Test

4

HSP90 inhibition downregulates DNA replication and repair genes via E2F1 repression

المؤلفون: Lanlan Liu, Hanqing Liu, Xiaofeng Shi, Zhigang Tu, Lu Ziwen, Peishan Zhang, Erica A. Golemis

المصدر: The Journal of Biological Chemistry

مصطلحات موضوعية: TF, transcription factor, DNA Repair, Ganetespib, Apoptosis, BTK, Bruton's tyrosine kinase, Lymphoma, Mantle-Cell, Biochemistry, Mice, E2F1, CDK, cyclin-dependent kinase, CDC, cell division cycle, ORC, origin recognition complex, biology, mTOR, mechanistic target of rapamycin, EdU, 5-ethynyl-2′-deoxyuridine, Gene Expression Regulation, Neoplastic, PRIM1, DNA primase polypeptide 1, qRT-PCR, quantitative RT-PCR, Signal Transduction, Research Article, DNA Replication, DNA repair, ganetespib, mantle cell lymphoma, Mice, Nude, HSP90, heat shock protein 90, Minichromosome maintenance, CHX, cycloheximide, FBS, fetal bovine serum, MCM, minichromosome maintenance, Cyclin-dependent kinase, Cell Line, Tumor, MCL, mantle cell lymphoma, Animals, Humans, HSP90, IF, immunofluorescence, HSP90 Heat-Shock Proteins, Molecular Biology, Transcription factor, Cell Proliferation, co-IP, coimmunoprecipitation, ALK, anaplastic lymphoma kinase, RMI2, RecQ-mediated genome instability 2, Cell Biology, Triazoles, Xenograft Model Antitumor Assays, Cancer cell, biology.protein, Cancer research, Origin recognition complex, E2F1 Transcription Factor

الوصول الحر: https://explore.openaire.eu/search/publication?articleId=doi_dedup___::e0b8e02c6375b425e27d3be293415265Test
https://pubmed.ncbi.nlm.nih.gov/34302809Test

5

Identification of a druggable protein–protein interaction site between mutant p53 and its stabilizing chaperone DNAJA1

المؤلفون: Rama K. Mishra, Dandan Xu, Ryan Jones, Leyu Sun, Gary E. Schiltz, Xin Tong, Jie Liao, Guang Yu Yang

المصدر: The Journal of Biological Chemistry

مصطلحات موضوعية: 0301 basic medicine, Cyclin-Dependent Kinase Inhibitor p21, Mutant, DNAJA1, pancreatic cancer, Druggability, protein–protein docking, Mutation, Missense, DMSO, dimethyl sulfoxide, Biochemistry, Protein–protein interaction, 03 medical and health sciences, Mice, FBS, fetal bovine serum, Cell Line, Tumor, interacting pocket, wtp53, wildtype p53, Hsp, heat shock protein, WT, wildtype, Animals, Humans, Homology modeling, homology model, Molecular Biology, CHIP, C terminus of Hsc70-interacting protein, KO, knockout, 030102 biochemistry & molecular biology, biology, Chemistry, Protein Stability, mutant p53, mutp53, mutant p53, Wild type, Cell Biology, Editors' Pick, HSP40 Heat-Shock Proteins, Small molecule, Cell biology, 030104 developmental biology, Amino Acid Substitution, Gene Expression Regulation, in silico, Chaperone (protein), biology.protein, DNAJA1, DnaJ homolog subfamily A member 1, Small molecule binding, Tumor Suppressor Protein p53, Research Article

الوصول الحر: https://explore.openaire.eu/search/publication?articleId=doi_dedup___::0d3f6e1d9d82b22ad12b655cfb8a1007Test
http://europepmc.org/articles/PMC7948449Test

6

Inhibition of Heat Shock Protein 90 Prevents HIV Rebound*

المؤلفون: Ekaterina Maidji, Cheryl A. Stoddart, Pheroze Joshi

المصدر: The Journal of Biological Chemistry

مصطلحات موضوعية: 0301 basic medicine, CD4-Positive T-Lymphocytes, viral rebound, Lactams, Macrocyclic, 030106 microbiology, Blotting, Western, Viremia, HIV Infections, Mice, SCID, Biochemistry, Antiviral Agents, Virus, 03 medical and health sciences, Mice, Mice, Inbred NOD, Heat shock protein, Virus latency, medicine, Benzoquinones, Animals, Humans, viral transcription, persistent reservoir, HSP90 Heat-Shock Proteins, Molecular Biology, Transcription factor, STAT5, transcription factor, biology, NFAT, Molecular Bases of Disease, Cell Biology, medicine.disease, hyperthermia, Hsp90, Virology, 3. Good health, Virus Latency, human immunodeficiency virus (HIV), 030104 developmental biology, Immunology, heat shock protein 90 (Hsp90), biology.protein, HIV-1, Leukocytes, Mononuclear, Female

الوصول الحر: https://explore.openaire.eu/search/publication?articleId=doi_dedup___::def0d750da3fc71301dca784c7706198Test
http://europepmc.org/articles/PMC4858980Test

7

Pharmacological induction of heat shock proteins ameliorates toxicity of mutant PKCγ in spinocerebellar ataxia type 14

المؤلفون: Naoko Adachi, Hideyuki Takahashi, Naoaki Saito, Takehiko Ueyama, Takahiro Seki, Norio Sakai, Aoi Nakazono, Daizo Hamada

المصدر: The Journal of biological chemistry. 293(38)

مصطلحات موضوعية: 0301 basic medicine, Amyloid, Detergents, Biochemistry, Cell Line, 03 medical and health sciences, chemistry.chemical_compound, neurodegenerative disease, spinocerebellar ataxia, Heat shock protein, Cerebellum, medicine, heat shock protein (HSP), Animals, Humans, Spinocerebellar Ataxias, PKC, Protein kinase A, Molecular Biology, Heat-Shock Proteins, Protein Kinase C, Hsp40, biology, Chemistry, protein kinase C (PKC), ataxia, Molecular Bases of Disease, Cell Biology, 70-kilodalton heat shock protein (Hsp70), medicine.disease, Hsp90, Hsp70, Cell biology, Up-Regulation, 030104 developmental biology, chaperone protein, Protein kinase domain, Rifabutin, Solubility, Celastrol, SCA14, heat shock protein 90 (Hsp90), Mutation, Spinocerebellar ataxia, biology.protein

وصف الملف: application/pdf

الوصول الحر: https://explore.openaire.eu/search/publication?articleId=doi_dedup___::283489869005571b2ef9a445dcfa6b6cTest
https://pubmed.ncbi.nlm.nih.gov/30093405Test

8

Heat shock protein 90 regulates soluble guanylyl cyclase maturation by a dual mechanism

المؤلفون: Mohammad Mahfuzul Haque, Simon Schlanger, Dennis J. Stuehr, Yue Dai, Saurav Misra

المصدر: J Biol Chem

الوصول الحر: https://explore.openaire.eu/search/publication?articleId=doi_dedup___::b5fc3c1ebf729dcfa751915e448f7b87Test
https://pubmed.ncbi.nlm.nih.gov/31311859Test

9

Roles of the endoplasmic reticulum-resident, collagen-specific molecular chaperone Hsp47 in vertebrate cells and human disease

المؤلفون: Kazuhiro Nagata, Shinya Ito

المصدر: The Journal of biological chemistry. 294(6)

الوصول الحر: https://explore.openaire.eu/search/publication?articleId=doi_dedup___::0e45d3cab8f08e03c3c32e26792f0d65Test
https://pubmed.ncbi.nlm.nih.gov/30541925Test

10

Correction: Regulation of ubiquitin-like with plant homeodomain and RING finger domain 1 (UHRF1) protein stability by heat shock protein 90 chaperone machinery

المؤلفون: Jia Li, Jiemin Wong, Yi Zang, Hui Zhang, Jiwen Li, Xiaojie Huang, Peilin Chen, Guangjin Ding

المصدر: The Journal of biological chemistry. 293(45)

الوصول الحر: https://explore.openaire.eu/search/publication?articleId=doi_dedup___::1c1e303fdcbd320bcf5417996810f560Test
https://pubmed.ncbi.nlm.nih.gov/27489107Test

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