Prospect of divergent roles for the CUL3 system in vascular endothelial cell function and angiogenesis
| العنوان: | Prospect of divergent roles for the CUL3 system in vascular endothelial cell function and angiogenesis |
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| المؤلفون: | Hironao Nakayama, Masashi Maekawa, Tomohisa Sakaue, Shigeki Higashiyama |
| المصدر: | The Journal of Biochemistry. |
| بيانات النشر: | Oxford University Press (OUP), 2017. |
| سنة النشر: | 2017 |
| مصطلحات موضوعية: | 0301 basic medicine, Neovascularization, Pathologic, biology, Angiogenesis, Cullin Proteins, Regeneration (biology), Endothelial Cells, General Medicine, Biochemistry, Ubiquitin ligase, Cell biology, Endothelial stem cell, 03 medical and health sciences, Crosstalk (biology), 030104 developmental biology, biology.protein, Humans, Wound healing, Molecular Biology, Cullin |
| الوصف: | Tissue remodelling and regeneration in various pathophysiological conditions (e.g. the processes of development, pregnancy, inflammation, wound healing, tissue regeneration, tumor growth, etc.) require angiogenesis, a dynamically coordinated response to stimuli from the extracellular microenvironment. During angiogenic and angiostatic responses, endothelial cells play a central role in the blood vessel formation and regression. Angiostatic responses, which are evoked by crucial factors such as VEGF and DLL4, have been elucidated. However, it has not been revealed, how endothelial cells process these conflicting signals. The study of VEGFR-Notch cross-signalling provided some clues. We discuss here the potential roles of cullin 3-based ubiquitin E3 ligases as key players in the process of various signals in endothelial cell function and angiogenesis. Our recent findings show that they function as units to process conflicting signalling crosstalk, epigenetic regulation of key factors, and functional barrier maintenance. We also expect more divergent roles of cullin 3-based ubiquitin E3 ligases in endothelial cell function and angiogenesis, and for their potential use as therapeutic targets. |
| تدمد: | 1756-2651 0021-924X |
| الوصول الحر: | https://explore.openaire.eu/search/publication?articleId=doi_dedup___::bd19718f8b116c0b5fa1e301bf12a4efTest https://doi.org/10.1093/jb/mvx051Test |
| حقوق: | OPEN |
| رقم الانضمام: | edsair.doi.dedup.....bd19718f8b116c0b5fa1e301bf12a4ef |
| قاعدة البيانات: | OpenAIRE |
| تدمد: | 17562651 0021924X |
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