The effect of the natural flavonoid cyanidin (IdB 1027), 1200mg daily for 8 days, on the fall in gastric transmucosal potential difference induced by a single dose of aspirin (1000mg by nasogastric tube) was evaluated in 7 normal male volunteers. As compared to pretreatment values, IdB 1027 caused a significant reduction in both the percentage fall in transmucosal potential difference at the time of peak aspirin effect (from 37 +/- 18% to 18 +/- 5%, p less than 0.05) and the area under potential difference baseline (from 811 +/- 624 mvolt. min to 338 +/- 150 mvolt. min, p less than 0.05). These results provide evidence for a protecting effect of IdB 1027 against aspirin-induced gastric mucosal damage in man.
