The various shades of ER‐phagy
| العنوان: | The various shades of ER‐phagy |
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| المؤلفون: | Paolo Grumati, Alexandra Stolz |
| المساهمون: | Stolz, Alexandra, Grumati, Paolo |
| المصدر: | The Febs Journal |
| بيانات النشر: | John Wiley and Sons Inc., 2019. |
| سنة النشر: | 2019 |
| مصطلحات موضوعية: | 0301 basic medicine, autophagy, ER-phagy, GABARAP, Endoplasmic Reticulum, Biochemistry, Models, Biological, 03 medical and health sciences, 0302 clinical medicine, Viewpoint, Lysosome, Organelle, medicine, Animals, Humans, Endoplasmic Reticulum Stre, Receptor, ER‐phagy, Membrane Protein, Molecular Biology, Animal, Chemistry, Endoplasmic reticulum, Autophagy, Membrane Proteins, Cell Biology, Endoplasmic Reticulum Stress, Cell biology, Viewpoints, 030104 developmental biology, medicine.anatomical_structure, 030220 oncology & carcinogenesis, Proteome, lysosome, Lysosomes, Homeostasis, Human |
| الوصف: | Endoplasmic reticulum (ER) is a large and dynamic cellular organelle. ER morphology consists of sheets, tubules, matrixes, and contact sites shared with other membranous organelles. The capacity of the ER to fulfill its numerous biological functions depends on its continuous remodeling and the quality control of its proteome. Selective turnover of the ER by autophagy, termed ER‐phagy, plays an important role in maintaining ER homeostasis. ER network integrity and turnover rely on specific ER‐phagy receptors, which influence and coordinate alterations in ER morphology and the degradation of ER contents and membranes via the lysosome, by interacting with the LC3/GABARAP family. In this commentary, we discuss general principles and identify the major players in this recently characterized form of selective autophagy, while simultaneously highlighting open questions in the field. The endoplasmic reticulum (ER) is a large and dynamic cellular organelle. Its capacity to fulfill the numerous biological functions depends on its continuous remodeling and the quality control of its proteome. Selective turnover of the ER (ER‐phagy) maintains ER homeostasis. ER network integrity and turnover rely on specific ER‐phagy receptors, which influence and coordinate alterations in ER morphology and the degradation of ER contents and membranes via the lysosome. |
| اللغة: | English |
| تدمد: | 1742-4658 1742-464X |
| الوصول الحر: | https://explore.openaire.eu/search/publication?articleId=doi_dedup___::839ce040fd307e084317160f7c5296c5Test http://europepmc.org/articles/PMC6916603Test |
| حقوق: | OPEN |
| رقم الانضمام: | edsair.doi.dedup.....839ce040fd307e084317160f7c5296c5 |
| قاعدة البيانات: | OpenAIRE |
| تدمد: | 17424658 1742464X |
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