دورية
A point mutation in the mitochondrial DNA of diabetes‐prone BHE/cdb rats1
| العنوان: | A point mutation in the mitochondrial DNA of diabetes‐prone BHE/cdb rats1 |
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| المؤلفون: | Mathews, Clayton E., McGraw, Royala., Berdamer, Carolyn D. |
| المصدر: | The FASEB Journal; December 1995, Vol. 9 Issue: 15 p1638-1642, 5p |
| مستخلص: | Mitochondrial DNA was extracted from hepatic tissue of 50‐ and 300‐day‐old male BHE/cdb and Sprague‐Dawley rats. The complete gene for the F0ATPase subunits 6 and 8 was sequenced. Four nucleotide substitutions were found: three of the substitutions were silent; the other substitution at position 523 was not. Its codon dictates the substitution of asparagine for aspartic acid in a critical location (in the polar pocket) of the F0AT‐ Pase. It is possible that this point mutation may explain previously reported decreases in ATP synthesis efficiency in BHE/cdb rats compared to Spra‐ gue‐Dawley rats.—Mathews, C. E., McGraw, R. A., Berdanier, C. D. A point mutation in the mitochondrial DNA of diabetes‐prone BHE/cdb rats. FASEB J.9, 1638‐1642 (1995) |
| قاعدة البيانات: | Supplemental Index |
| تدمد: | 08926638 15306860 |
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| DOI: | 10.1096/fasebj.9.15.8529844 |