WNT4 is a key regulator of normal postnatal uterine development and progesterone signaling during embryo implantation and decidualization in the mouse
| العنوان: | WNT4 is a key regulator of normal postnatal uterine development and progesterone signaling during embryo implantation and decidualization in the mouse |
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| المؤلفون: | Kevin Y. Lee, Heather L. Franco, Milan K. Bagchi, Dennis R. Roop, Derek Boerboom, Francesco J. DeMayo, Daisy Dai, John P. Lydon, Jae Wook Jeong, Cory A. Rubel, Indrani C. Bagchi |
| المصدر: | The FASEB Journal. 25:1176-1187 |
| بيانات النشر: | Wiley, 2010. |
| سنة النشر: | 2010 |
| مصطلحات موضوعية: | medicine.medical_specialty, animal structures, Stromal cell, Uterus, Apoptosis, Biology, Biochemistry, Research Communications, Andrology, Mice, 03 medical and health sciences, 0302 clinical medicine, Pregnancy, Wnt4 Protein, Internal medicine, WNT4, Decidua, Genetics, medicine, Animals, Embryo Implantation, Molecular Biology, Progesterone, 030304 developmental biology, Endometrial Stromal Cell, 0303 health sciences, 030219 obstetrics & reproductive medicine, Wnt signaling pathway, Decidualization, Embryo, Wnt Proteins, medicine.anatomical_structure, Endocrinology, Female, Signal Transduction, Biotechnology |
| الوصف: | WNT4, a member of the Wnt family of ligands, is critical for the development of the female reproductive tract. Analysis of Wnt4 expression in the adult uterus during pregnancy indicates that it may play a role in the regulation of endometrial stromal cell proliferation, survival, and differentiation, which is required to support the developing embryo. To investigate the role of Wnt4 in adult uterine physiology, conditional ablation of Wnt4 using the PRcre mouse model was accomplished. Ablation of Wnt4 rendered female mice subfertile due to a defect in embryo implantation and subsequent defects in endometrial stromal cell survival, differentiation, and responsiveness to progesterone signaling. In addition to altered stromal cell function, the uteri of PRcre/+Wnt4f/f (Wnt4d/d) mice displayed altered epithelial differentiation characterized by a reduction in the number of uterine glands and the emergence of a p63-positive basal cell layer beneath the columnar luminal epithelial cells. The altered epithelial cell phenotype was further escalated by chronic estrogen treatment, which caused squamous cell metaplasia of the uterine epithelium in the Wnt4d/d mice. Thus, WNT4 is a critical regulator not only of proper postnatal uterine development, but also embryo implantation and decidualization.—Franco, H. L., Dai, D., Lee, K. Y., Rubel, C. S., Roop, D., Boerboom, D., Jeong, J.-W., Lydon, J.-P., Bagchi, I. C., Bagchi, M. K., DeMayo, F. J. WNT4 is a key regulator of normal postnatal uterine development and progesterone signaling during embryo implantation and decidualization in the mouse. |
| تدمد: | 1530-6860 0892-6638 |
| الوصول الحر: | https://explore.openaire.eu/search/publication?articleId=doi_dedup___::090cd0c9d6ce5c80b6d6d75c63d4fb3fTest https://doi.org/10.1096/fj.10-175349Test |
| حقوق: | OPEN |
| رقم الانضمام: | edsair.doi.dedup.....090cd0c9d6ce5c80b6d6d75c63d4fb3f |
| قاعدة البيانات: | OpenAIRE |
| تدمد: | 15306860 08926638 |
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