The effects of excessive selenium metabolism on gene expression of HepG2 cells
| العنوان: | The effects of excessive selenium metabolism on gene expression of HepG2 cells |
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| المؤلفون: | Hao-Ai Shui, Yu Hsin Chen, Feili Lo Yang, Han-Min Chen |
| المصدر: | The FASEB Journal. 22 |
| بيانات النشر: | Wiley, 2008. |
| سنة النشر: | 2008 |
| مصطلحات موضوعية: | Chemistry, Cell growth, Cellular differentiation, Metabolism, Proteomics, Biochemistry, Nucleoside-diphosphate kinase, Cell biology, chemistry.chemical_compound, Immune system, Genetics, Prohibitin, Molecular Biology, DNA, Biotechnology |
| الوصف: | High selenium (Se) level in the culture medium was reported to delay cell growth and to cause morphological changes of HepG2 cells in our previous study. The purpose of this study was to use proteomic technique to explore the influence of excessive Se metabolism on the protein expression of HepG2 cells. After 24 hr of exposure in 20 μM of sodium selenite in medium, the expression of at least 30 proteins was significantly altered. Nine of the up-regulated proteins included those participated in immune response (immunoglobulin heavy chain), collagen formation (proline 4-hydroxylase), energy metabolism (mitochondrial ATP synthase), tumor suppressor protein (prohibitin), cell growth (FUBP1 protein, galectin-3 carbohydrate recognition domain), and cell differentiation (human nucleoside diphosphate kinase, galectin-3 carbohydrate recognition domain). The expression of 21 proteins was down regulated, which also included some proteins in the cellular activities such as energy metabolism, immune response, DNA repl... |
| تدمد: | 1530-6860 0892-6638 |
| الوصول الحر: | https://explore.openaire.eu/search/publication?articleId=doi_________::9d2173eca3139d642ec40abd58bf5611Test https://doi.org/10.1096/fasebj.22.1_supplement.696.8Test |
| حقوق: | OPEN |
| رقم الانضمام: | edsair.doi...........9d2173eca3139d642ec40abd58bf5611 |
| قاعدة البيانات: | OpenAIRE |
| تدمد: | 15306860 08926638 |
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