Structure and mechanism of action of the Acyl‐CoA dehydrogenases 1
| العنوان: | Structure and mechanism of action of the Acyl‐CoA dehydrogenases 1 |
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| المؤلفون: | Jujng-Ja P. Kim, Colin Thorpe |
| المصدر: | The FASEB Journal. 9:718-725 |
| بيانات النشر: | Wiley, 1995. |
| سنة النشر: | 1995 |
| مصطلحات موضوعية: | chemistry.chemical_classification, biology, Chemistry, Acyl CoA dehydrogenase, Flavoprotein, Dehydrogenase, Biochemistry, Electron-transferring flavoprotein, Residue (chemistry), Enzyme, Mechanism of action, Genetics, medicine, biology.protein, medicine.symptom, Molecular Biology, Beta oxidation, Biotechnology |
| الوصف: | Mitochondrial beta-oxidation involves a family of flavoproteins that introduce a C-C double bond into their fatty acyl-CoA substrates. Deficiencies of these acyl-CoA dehydrogenases lead to fatty acid oxidation disorders involving life-threatening episodes of metabolic derangement. This review focuses on the medium chain acyl-CoA dehydrogenase as the best-understood member of its class. The crystal structure of the enzyme and salient features of its substrate specificity and mechanism of action are summarized. The surprising observation of a catalytically essential amino acid residue that nevertheless is not conserved in the acyl-CoA dehydrogenase family is discussed. |
| تدمد: | 1530-6860 0892-6638 |
| الوصول الحر: | https://explore.openaire.eu/search/publication?articleId=doi_________::c13948bb1359ca6b891501349212d483Test https://doi.org/10.1096/fasebj.9.9.7601336Test |
| حقوق: | CLOSED |
| رقم الانضمام: | edsair.doi...........c13948bb1359ca6b891501349212d483 |
| قاعدة البيانات: | OpenAIRE |
| تدمد: | 15306860 08926638 |
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