المؤلفون: Manal Mohsen, Ahmed Shawky

المصدر: The Egyptian Heart Journal, Vol 68, Iss 1, Pp 1-9 (2016)

مصطلحات موضوعية: Acute coronary syndrome, Cardiac biomarkers, High sensitivity Troponin, Diseases of the circulatory (Cardiovascular) system, RC666-701

الوصف: Background: Coronary artery disease (CAD), its acute form, and acute coronary syndrome (ACS) are the leading cause of death all over the world. For initial assessment of a patient with ACS, ECG, imaging techniques and serum biomarkers all contribute in confirming the diagnosis. Cardiac Troponin (cTn) I and T are the current gold standard for the detection of myocardial necrosis. However, there is also emerging evidence suggesting that with the use of sensitive or high-sensitive cTn assays, a blood sample collected 2 or 3 h after presentation might be appropriate for an earlier rule in and rule out diagnosis of AMI compared with the recommended second blood draw 6–9 h after admission using conventional Troponin assay. Aim: The aim of this study was to examine the ability of High-Sensitivity Cardiac Troponin T for early detection of AMI in comparison with conventional Troponin assay. In addition, to study the clinical utility of kinetic changes of High-Sensitivity Cardiac Troponin T for diagnosis of ACS. Methods: This study was conducted on sixty subjects. Fifty patients who presented to emergency department in Ain-Shams University Hospital complaining of chest pain were highly suspicious to have acute cardiac ischemia, having no or non-specific ECG changes and their Cardiac Troponin I level on admission was below the test threshold value (100 ng/L). In addition, ten subjects serving as a healthy control group were also recruited. The fifty patients were subdivided into subgroup A which included 16 patients, with hs-TnT

وصف الملف: electronic resource

العلاقة: http://www.sciencedirect.com/science/article/pii/S1110260814001227Test; https://doaj.org/toc/1110-2608Test

الوصول الحر: https://doaj.org/article/1a5a3d543a394f7b86a2374b91fc316cTest

المؤلفون: Ahmed M. Shawky, Manal Mohsen

المصدر: The Egyptian Heart Journal, Vol 68, Iss 1, Pp 1-9 (2016)

مصطلحات موضوعية: medicine.medical_specialty, Acute coronary syndrome, lcsh:Diseases of the circulatory (Cardiovascular) system, High sensitivity Troponin, 030204 cardiovascular system & hematology, Chest pain, Coronary artery disease, 03 medical and health sciences, 0302 clinical medicine, Internal medicine, Troponin I, Medicine, 030212 general & internal medicine, biology, Receiver operating characteristic, business.industry, Gold standard (test), Emergency department, medicine.disease, Troponin, Cardiac biomarkers, lcsh:RC666-701, biology.protein, Cardiology, medicine.symptom, Cardiology and Cardiovascular Medicine, business

الوصف: Background: Coronary artery disease (CAD), its acute form, and acute coronary syndrome (ACS) are the leading cause of death all over the world. For initial assessment of a patient with ACS, ECG, imaging techniques and serum biomarkers all contribute in confirming the diagnosis. Cardiac Troponin (cTn) I and T are the current gold standard for the detection of myocardial necrosis. However, there is also emerging evidence suggesting that with the use of sensitive or high-sensitive cTn assays, a blood sample collected 2 or 3 h after presentation might be appropriate for an earlier rule in and rule out diagnosis of AMI compared with the recommended second blood draw 6–9 h after admission using conventional Troponin assay. Aim: The aim of this study was to examine the ability of High-Sensitivity Cardiac Troponin T for early detection of AMI in comparison with conventional Troponin assay. In addition, to study the clinical utility of kinetic changes of High-Sensitivity Cardiac Troponin T for diagnosis of ACS. Methods: This study was conducted on sixty subjects. Fifty patients who presented to emergency department in Ain-Shams University Hospital complaining of chest pain were highly suspicious to have acute cardiac ischemia, having no or non-specific ECG changes and their Cardiac Troponin I level on admission was below the test threshold value (100 ng/L). In addition, ten subjects serving as a healthy control group were also recruited. The fifty patients were subdivided into subgroup A which included 16 patients, with hs-TnT

الوصول الحر: https://explore.openaire.eu/search/publication?articleId=doi_dedup___::3daaef6ac151c932e9b205302f9103cfTest