Pioglitazone use and risk of bladder cancer: population based cohort study
| العنوان: | Pioglitazone use and risk of bladder cancer: population based cohort study |
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| المؤلفون: | Marco Tuccori, Robert W. Platt, Hui Yin, Oriana Hoi Yun Yu, Laurent Azoulay, Kristian B. Filion |
| المصدر: | The BMJ |
| بيانات النشر: | BMJ Publishing Group Ltd., 2016. |
| سنة النشر: | 2016 |
| مصطلحات موضوعية: | medicine.medical_specialty, Bladder cancer, business.industry, medicine.drug_class, Proportional hazards model, Research, Hazard ratio, 030209 endocrinology & metabolism, General Medicine, medicine.disease, 3. Good health, Surgery, 03 medical and health sciences, 0302 clinical medicine, Internal medicine, Cohort, Medicine, 030212 general & internal medicine, Thiazolidinedione, business, Rosiglitazone, Pioglitazone, Cohort study, medicine.drug |
| الوصف: | Objective To determine whether pioglitazone compared with other antidiabetic drugs is associated with an increased risk of bladder cancer in people with type 2 diabetes. Design Population based cohort study. Setting General practices contributing data to the United Kingdom Clinical Practice Research Datalink. Participants A cohort of 145 806 patients newly treated with antidiabetic drugs between 1 January 2000 and 31 July 2013, with follow-up until 31 July 2014. Main outcome measures The use of pioglitazone was treated as a time varying variable, with use lagged by one year for latency purposes. Cox proportional hazards models were used to estimate adjusted hazard ratios with 95% confidence intervals of incident bladder cancer associated with pioglitazone overall and by both cumulative duration of use and cumulative dose. Similar analyses were conducted for rosiglitazone, a thiazolidinedione not previously associated with an increased risk of bladder cancer. Results The cohort generated 689 616 person years of follow-up, during which 622 patients were newly diagnosed as having bladder cancer (crude incidence 90.2 per 100 000 person years). Compared with other antidiabetic drugs, pioglitazone was associated with an increased risk of bladder cancer (121.0 v 88.9 per 100 000 person years; hazard ratio 1.63, 95% confidence interval 1.22 to 2.19). Conversely, rosiglitazone was not associated with an increased risk of bladder cancer (86.2 v 88.9 per 100 000 person years; 1.10, 0.83 to 1.47). Duration-response and dose-response relations were observed for pioglitazone but not for rosiglitazone. Conclusion The results of this large population based study indicate that pioglitazone is associated with an increased risk of bladder cancer. The absence of an association with rosiglitazone suggests that the increased risk is drug specific and not a class effect. |
| اللغة: | English |
| تدمد: | 1756-1833 0959-8138 |
| الوصول الحر: | https://explore.openaire.eu/search/publication?articleId=doi_dedup___::03fefc42cac273a098a71e7d6bcd4880Test http://europepmc.org/articles/PMC4816602Test |
| حقوق: | OPEN |
| رقم الانضمام: | edsair.doi.dedup.....03fefc42cac273a098a71e7d6bcd4880 |
| قاعدة البيانات: | OpenAIRE |
| تدمد: | 17561833 09598138 |
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