High Mortality and Coinfection in a Prospective Cohort of Human Immunodeficiency Virus/Acquired Immune Deficiency Syndrome Patients with Histoplasmosis in Guatemala
| العنوان: | High Mortality and Coinfection in a Prospective Cohort of Human Immunodeficiency Virus/Acquired Immune Deficiency Syndrome Patients with Histoplasmosis in Guatemala |
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| المؤلفون: | Monika Roy, Narda Medina, Eduardo Arathoon, Beatriz L. Gómez, Angela A. Cleveland, Blanca Samayoa, Tom Chiller, Dalia Lau-Bonilla, Christina M. Scheel |
| المصدر: | Repositorio EdocUR-U. Rosario Universidad del Rosario instacron:Universidad del Rosario |
| سنة النشر: | 2017 |
| مصطلحات موضوعية: | 0301 basic medicine, Male, Pediatrics, Survival, AIDS-related complex, Median survival time, HIV Infections, Cohort Studies, 0302 clinical medicine, Interquartile range, Cause of Death, Mixed infection, Prospective Studies, AIDS related complex, Middle aged, Fluconazole, Antifungal therapy, Histoplasmosis, Aged, 80 and over, education.field_of_study, biology, Ajellomyces capsulatus, Coinfection, Mortality rate, Articles, Middle Aged, Guatemala, Antiretroviral therapy, Infectious Diseases, Acquired immune deficiency syndrome, Mycobacteriosis, Medical history, Female, Itraconazole, Cohort analysis, Human, Adult, medicine.medical_specialty, AIDS-Related Opportunistic Infections, 030106 microbiology, 030231 tropical medicine, Population, Histoplasma, Cause of death, Article, 03 medical and health sciences, Young Adult, Human immunodeficiency virus infection, Virology, Amphotericin B, medicine, Humans, Prospective study, Mortality, education, Infection sensitivity, Antiretrovirus agent, Aged, Acquired Immunodeficiency Syndrome, business.industry, Very elderly, medicine.disease, biology.organism_classification, Clinical feature, Isolation and purification, Immunology, Parasitology, business, Complication |
| الوصف: | Histoplasmosis is one of the most common and deadly opportunistic infections among persons living with human immunodeficiency virus (HIV)/acquired immune deficiency syndrome in Latin America, but due to limited diagnostic capacity in this region, few data on the burden and clinical characteristics of this disease exist. Between 2005 and 2009, we enrolled patients 18 years of age with suspected histoplasmosis at a hospital-based HIV clinic in Guatemala City. A case of suspected histoplasmosis was defined as a person presenting with at least three of five clinical or radiologic criteria. A confirmed case of histoplasmosis was defined as a person with a positive culture or urine antigen test for Histoplasma capsulatum. Demographic and clinical data were also collected and analyzed. Of 263 enrolled as suspected cases of histoplasmosis, 101 (38.4%) were confirmed cases. Median time to diagnosis was 15 days after presentation (interquartile range [IQR] = 5-23). Crude overall mortality was 43.6%; median survival time was 19 days (IQR = 4-69). Mycobacterial infection was diagnosed in 70 (26.6%) cases; 26 (25.7%) histoplasmosis cases were coinfected with mycobacteria. High mortality and short survival time after initial symptoms were observed in patients with histoplasmosis. Mycobacterial coinfection diagnoses were frequent, highlighting the importance of pursuing diagnoses for both diseases. and copy; 2017 by The American Society of Tropical Medicine and Hygiene. |
| وصف الملف: | application/pdf |
| تدمد: | 1476-1645 |
| الوصول الحر: | https://explore.openaire.eu/search/publication?articleId=doi_dedup___::68d9cdd87b5930c9885efa119725946cTest https://pubmed.ncbi.nlm.nih.gov/28719316Test |
| حقوق: | OPEN |
| رقم الانضمام: | edsair.doi.dedup.....68d9cdd87b5930c9885efa119725946c |
| قاعدة البيانات: | OpenAIRE |
| تدمد: | 14761645 |
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