Relationship Between Exposure, Clinical Malaria, and Age in an Area of Changing Transmission Intensity
| العنوان: | Relationship Between Exposure, Clinical Malaria, and Age in an Area of Changing Transmission Intensity |
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| المؤلفون: | Tabitha W. Mwangi, Robert W. Snow, F. Ellis McKenzie, Kevin Marsh, Thomas N. Williams, Wendy Prudhomme O’Meara |
| المصدر: | The American Journal of Tropical Medicine and Hygiene. 79:185-191 |
| بيانات النشر: | American Society of Tropical Medicine and Hygiene, 2008. |
| سنة النشر: | 2008 |
| مصطلحات موضوعية: | medicine.medical_specialty, education.field_of_study, Pediatrics, business.industry, Incidence (epidemiology), Public health, Population, medicine.disease, law.invention, Infectious Diseases, Transmission (mechanics), law, Virology, parasitic diseases, Tropical medicine, Epidemiology, Medicine, Parasitology, Transmission intensity, business, education, Malaria, Demography |
| الوصف: | The relationship between malaria transmission intensity and clinical disease is important for predicting the outcome of control measures that reduce transmission. Comparisons of hospital data between areas of differing transmission intensity suggest that the mean age of hospitalized clinical malaria is higher under relatively lower transmission, but the total number of episodes is similar until transmission drops below a threshold, where the risks of hospitalized malaria decline. These observations have rarely been examined longitudinally in a single community where transmission declines over time. We reconstructed 16 years (1991-2006) of pediatric hospital surveillance data and infection prevalence surveys from a circumscribed geographic area on the Kenyan coast. The incidence of clinical malaria remained high, despite sustained reductions in exposure to infection. However, the age group experiencing the clinical attacks of malaria increased steadily as exposure declined and may precede changes in the number of episodes in an area with declining transmission. |
| تدمد: | 1476-1645 0002-9637 |
| الوصول الحر: | https://explore.openaire.eu/search/publication?articleId=doi_dedup___::b310e1473f078334c9d16a1fd5bd1c22Test https://doi.org/10.4269/ajtmh.2008.79.185Test |
| حقوق: | OPEN |
| رقم الانضمام: | edsair.doi.dedup.....b310e1473f078334c9d16a1fd5bd1c22 |
| قاعدة البيانات: | OpenAIRE |
| تدمد: | 14761645 00029637 |
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