Impact of Biannual Azithromycin on Anemia in Preschool Children in Kilosa District, Tanzania: A Cluster-Randomized Clinical Trial
| العنوان: | Impact of Biannual Azithromycin on Anemia in Preschool Children in Kilosa District, Tanzania: A Cluster-Randomized Clinical Trial |
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| المؤلفون: | Evan M. Bloch, Sheila K. West, Beatriz Munoz, Zakayo Mrango, Jerusha Weaver, Thomas M. Lietman |
| المصدر: | The American journal of tropical medicine and hygiene, vol 103, iss 3 The American Journal of Tropical Medicine and Hygiene |
| بيانات النشر: | American Society of Tropical Medicine and Hygiene, 2020. |
| سنة النشر: | 2020 |
| مصطلحات موضوعية: | Pediatrics, medicine.medical_specialty, Anemia, Cross-sectional study, 030231 tropical medicine, Azithromycin, Disease cluster, Placebo, Tanzania, Medical and Health Sciences, law.invention, 03 medical and health sciences, 0302 clinical medicine, Randomized controlled trial, law, Tropical Medicine, hemic and lymphatic diseases, Virology, Prevalence, medicine, Humans, Child, Preschool, biology, business.industry, Infant, Articles, medicine.disease, biology.organism_classification, Anti-Bacterial Agents, Clinical trial, Cross-Sectional Studies, Infectious Diseases, Child, Preschool, Child Mortality, Mass Drug Administration, Parasitology, business, medicine.drug |
| الوصف: | A cluster-randomized clinical trial showed that biannual single-dose azithromycin reduced mortality in preschool children; we sought to determine the effect on anemia. A simple random sample of 30 communities from Kilosa district, Tanzania, were themselves randomized to receive either 6-monthly treatment of children aged 1–59 months with single-dose azithromycin or placebo. From each community, 40 preschool children were randomly selected at baseline, 12 months, and 24 months. At surveys, the children underwent hemoglobin testing; WHO definitions for anemia were applied. After adjusting for community clustering, the prevalence of anemia was not significantly different by treatment assignment at baseline, 12 months, and 24 months. In each of the cross-sectional surveys, anemia prevalence was associated with younger age; the odds of being anemic was highest in those aged < 12 months. There was also a general decrease in the prevalence of anemia during the study. Although azithromycin was not shown to affect anemia, significantly, the study highlights burden of anemia in rural, African communities. |
| وصف الملف: | application/pdf |
| تدمد: | 1476-1645 0002-9637 |
| الوصول الحر: | https://explore.openaire.eu/search/publication?articleId=doi_dedup___::9f17dc24391415d999be0e10f0e03631Test https://doi.org/10.4269/ajtmh.19-0500Test |
| حقوق: | OPEN |
| رقم الانضمام: | edsair.doi.dedup.....9f17dc24391415d999be0e10f0e03631 |
| قاعدة البيانات: | OpenAIRE |
| تدمد: | 14761645 00029637 |
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