Predicting Left Atrial Appendage Thrombus from Left Atrial Volume and Confirmation by Computed Tomography with Delayed Enhancement
| العنوان: | Predicting Left Atrial Appendage Thrombus from Left Atrial Volume and Confirmation by Computed Tomography with Delayed Enhancement |
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| المؤلفون: | Rine Nakanishi, Matthew J. Budoff, Kazuhiro Osawa, Negin Nezarat, William J. French, Indre Ceponiene |
| المصدر: | Tex Heart Inst J Texas Heart Institute journal, vol 47, iss 2 |
| سنة النشر: | 2020 |
| مصطلحات موضوعية: | Male, medicine.medical_specialty, Heart Diseases, Cardiac Volume, Atrial appendage/diagnostic imaging, Delayed enhancement, 030204 cardiovascular system & hematology, 030218 nuclear medicine & medical imaging, 03 medical and health sciences, 0302 clinical medicine, Left atrial, Predictive Value of Tests, Internal medicine, Atrial Fibrillation, Medicine, Humans, Atrial Appendage, cardiovascular diseases, Heart Atria, Prospective Studies, Clinical Investigation, Thrombus, Prospective cohort study, heart atria/diagnostic imaging, multidetector computed tomography/methods, Aged, Body surface area, Appendage, business.industry, risk assessment, Atrial fibrillation, Thrombosis, Odds ratio, thrombosis/diagnosis, Middle Aged, medicine.disease, Cardiovascular System & Hematology, Cardiology, cardiovascular system, Female, Cardiology and Cardiovascular Medicine, business, Tomography, X-Ray Computed |
| الوصف: | Assessing thromboembolic risk is crucial for proper management of patients with atrial fibrillation. Left atrial volume is a promising predictor of cardiac thrombosis. To determine whether left atrial volume can predict left atrial appendage thrombus in patients with atrial fibrillation, we conducted a prospective study of 73 patients. Left atrial and ventricular volumes were evaluated by cardiac computed tomography with retrospective electrocardiographic gating and then indexed to body surface area. Left atrial appendage thrombus was confirmed or excluded by cardiac computed tomography with delayed enhancement. Seven patients (9.6%) had left atrial appendage thrombus; 66 (90.4%) did not. Those with thrombus had a significantly higher mean left atrial end-systolic volume index (139 ± 55 vs 101 ± 35 mL/m2; P =0.0097) and mean left atrial end-diastolic volume index (122 ± 45 vs 84 ± 34 mL/m2; P =0.0077). On multivariate logistic regression analysis, left atrial end-systolic volume index (per 10 mL/m2 increase) was significantly associated with left atrial appendage thrombus (odds ratio [OR]=1.24; 95% CI, 1.03–1.50; P =0.02); so too was the left atrial end-diastolic volume index (per 10 mL/m2 increase) (OR=1.29; 95% CI, 1.05–1.60; P =0.02). These findings suggest that increased left atrial volume increases the risk of left atrial appendage thrombus. Therefore, patients with atrial fibrillation and an enlarged left atrium should be considered for cardiac computed tomography with delayed enhancement to confirm whether thrombus is present. |
| وصف الملف: | application/pdf |
| تدمد: | 1526-6702 |
| الوصول الحر: | https://explore.openaire.eu/search/publication?articleId=doi_dedup___::cb14cf15fbf1c4860b10ecbdc6a21059Test https://pubmed.ncbi.nlm.nih.gov/32603460Test |
| حقوق: | OPEN |
| رقم الانضمام: | edsair.doi.dedup.....cb14cf15fbf1c4860b10ecbdc6a21059 |
| قاعدة البيانات: | OpenAIRE |
| تدمد: | 15266702 |
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