رسالة جامعية
Self-assembled monolayers for biological applications: design, processing, characterization and biological studies
| العنوان: | Self-assembled monolayers for biological applications: design, processing, characterization and biological studies |
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| المؤلفون: | R. Kyvik, Adriana |
| المساهمون: | Ratera Bastardas, Imma, Palet i Ballús, Cristina, Universitat Autònoma de Barcelona. Departament de Química |
| المصدر: | TDX (Tesis Doctorals en Xarxa) |
| بيانات النشر: | Universitat Autònoma de Barcelona |
| سنة النشر: | 2019 |
| المجموعة: | Universitat Autònoma de Barcelona (UAB): Tesis Doctorals en Xarxa (TDX) / Theses and Dissertations Online |
| مصطلحات موضوعية: | Monocapes auto-asssemblades, Monocapaas asutoensambladas, Self-assembled monolayers, Monocapes electroactive, Monocapas electroactivas, Electroactive SAMs, Interfícies dinàmiques, Intercaras dinámicas, Dynamic interfaces, Ciències Experimentals |
| الوقت: | 54 |
| الوصف: | Self-assembled monolayers (SAMs) on gold surfaces have been designed, processed, characterized and used for specific biological studies. The studies performed include the control of lipid bilayer diffusion, cell adhesion and vascularization studies and also the creation of antimicrobial surfaces. More specifically, dynamic SAMs on surfaces whose properties can be modified with an electrochemical external stimulus have been developed and used to interrogate biological systems. The developed platform has been applied to two different applications to overcome present challenges when performing biological studies. Firstly, in Chapter 2, the design and synthesis of all the molecules needed to develop an electroactive platform, its processing as SAMs and the optimization of the surface confined redox process between a non-reactive Hydroquinone (HQ) termination and its corresponding reactive Benzoquinone (BQ) is reported. Two different interfacial reactions taking place on the electroactivated surfaces were studied in detail; the Diels-Alder (DA) and the Michael Addition (MA) interfacial reactions, with cyclopentadiene (Cp) or thiol tagged molecules, respectively. The comparative study between DA and MA as surface functionalization strategies with a temporal control reveal that even though MA is not commonly used for this purpose it offers an attractive strategy for stimulus activated functionalization for biological applications. In Chapter 3, the developed platform has been used to achieve a temporal control of cell adhesion and in this way mimic in vivo conditions more accurately. Cell adhesion plays fundamental roles in biological functions and as such, it is important to control cell adhesion on materials used for biomedical applications. Towards this aim, the dynamic interface developed has been used to immobilize cell adhesion promoting peptides through the two different interfacial reactions, namely the DA and the MA reaction, and a comparative study has been carried out. Moreover, a study involving immobilized ... |
| نوع الوثيقة: | doctoral or postdoctoral thesis |
| وصف الملف: | application/pdf; 217 p. |
| اللغة: | English |
| ردمك: | 978-84-490-8600-7 84-490-8600-0 |
| العلاقة: | http://hdl.handle.net/10803/666882Test |
| الإتاحة: | http://hdl.handle.net/10803/666882Test |
| حقوق: | L'accés als continguts d'aquesta tesi queda condicionat a l'acceptació de les condicions d'ús establertes per la següent llicència Creative Commons: http://creativecommons.org/licenses/by-nc-nd/4.0Test/ ; info:eu-repo/semantics/openAccess |
| رقم الانضمام: | edsbas.67226DCA |
| قاعدة البيانات: | BASE |
| ردمك: | 9788449086007 8449086000 |
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