دورية أكاديمية
Intelligent tunable CAR-T cell therapy leads the new trend
| العنوان: | Intelligent tunable CAR-T cell therapy leads the new trend |
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| المؤلفون: | Jiayi Cheng, Mingyao Liu, Jiqin Zhang |
| المصدر: | Synthetic and Systems Biotechnology, Vol 8, Iss 4, Pp 606-609 (2023) |
| بيانات النشر: | KeAi Communications Co., Ltd., 2023. |
| سنة النشر: | 2023 |
| المجموعة: | LCC:Biotechnology LCC:Biology (General) |
| مصطلحات موضوعية: | Chimeric antigen receptor T, Tumor, Safety and efficacy, On and off systems, Autologous universal system, Synthetic notch system, Biotechnology, TP248.13-248.65, Biology (General), QH301-705.5 |
| الوصف: | Adoptive transfer of T cells engineered with chimeric antigen receptor (CAR) has been proved to have robust anti-tumor effects against hematological malignancies. However, problems about safety and efficacy, such as cytokine release syndrome (CRS), T cell exhaustion and antigen escape are still raised when patients are treated with CAR-T cells. Moreover, CAR-T therapy has limited applications in treating solid tumors, owing to inefficient infiltration and poor functional persistence of CAR-T cells and diverse immunosuppression in tumor microenvironment. In order to overcome these limitations and broad its applications, multiple controllable CAR-T technologies were exploited. In this article, we review the designs of intelligent controlled CAR-T technologies and the innovations that they bring about in recent years. |
| نوع الوثيقة: | article |
| وصف الملف: | electronic resource |
| اللغة: | English |
| تدمد: | 2405-805X |
| العلاقة: | http://www.sciencedirect.com/science/article/pii/S2405805X23000753Test; https://doaj.org/toc/2405-805XTest |
| DOI: | 10.1016/j.synbio.2023.09.001 |
| الوصول الحر: | https://doaj.org/article/bb3d52bdebb948a984b008ee2d6b1417Test |
| رقم الانضمام: | edsdoj.bb3d52bdebb948a984b008ee2d6b1417 |
| قاعدة البيانات: | Directory of Open Access Journals |
Full Text Finder | تدمد: | 2405805X |
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| DOI: | 10.1016/j.synbio.2023.09.001 |