التفاصيل البيبلوغرافية
| العنوان: |
Synthesis of a Ubiquitinated Histone Mimic Bearing a New Thioether Linkage. |
| المؤلفون: |
Qiaoqiao He, Yunkun Qi, Chao Liu, Jiabin Li, Honggang Hu |
| المصدر: |
Synlett; 2017, Vol. 28 Issue 15, p1939-1943, 5p |
| مصطلحات موضوعية: |
HISTONES, UBIQUITINATION, SULFIDES |
| مستخلص: |
Current studies on histone ubiquitination require the development of more effective approaches for the preparation of ubiquitinated histones. Here, we report a new approach to obtain ubiquitinated histone mimics by using a thioether linkage. The synthetic ubiquitinated histone mimic is stable under reducing conditions and has the same atom number as the native structure. Biochemical experiments showed that the mimic is a good surrogate for natural ubiquitinated histone. [ABSTRACT FROM AUTHOR] |
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| قاعدة البيانات: |
Complementary Index |
