التفاصيل البيبلوغرافية
| العنوان: |
Beyond the cherry-red spot: Ocular manifestations of sphingolipid-mediated neurodegenerative and inflammatory disorders. |
| المؤلفون: |
Chen, Hui1,2, Chan, Annie Y.1,2, Stone, Donald U.1,2, Mandal, Nawajes A.1,2 mmandal@ouhsc.edu |
| المصدر: |
Survey of Ophthalmology. Jan2014, Vol. 59 Issue 1, p64-76. 13p. |
| مصطلحات موضوعية: |
*OCULAR manifestations of general diseases, *SPHINGOLIPIDS, *NEURODEGENERATION, *EYE inflammation, *MEMBRANE lipids, *TAY-Sachs disease, *NEOVASCULARIZATION |
| مستخلص: |
Abstract: Sphingolipids are a ubiquitous membrane lipid present in every cell and found most abundantly in neural tissues. Disorders such as Tay-Sachs or Niemann-Pick disease are the most familiar examples of dysfunction in sphingolipid metabolism and are typically associated with neurodegeneration and ocular findings such as blindness. More recently, the role of bioactive sphingolipids has been established in a multitude of cellular events, including cell survival, growth, senescence and apoptosis, inflammation, and neovascularization. We discuss our current knowledge and understanding of sphingolipid metabolism and signaling in the pathogenesis of ocular diseases. [Copyright &y& Elsevier] |
| قاعدة البيانات: |
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