التفاصيل البيبلوغرافية
| العنوان: |
Prognostic and predictive biomarkers for pancreatic neuroendocrine tumors |
| المؤلفون: |
Hackeng, Wenzel M., Assi, Hussein A., Westerbeke, Florine H.M., Brosens, Lodewijk A.A., Heaphy, Christopher M. |
| المصدر: |
Surgical Pathology Clinics; 20220101, Issue: Preprints |
| مستخلص: |
Pancreatic neuroendocrine tumors (PanNETs) represent a clinically challenging disease, since these tumors vary in clinical presentation, natural history, and prognosis. Novel prognostic biomarkers are needed to improve patient stratification and treatment options. Several putative prognostic and/or predictive biomarkers (e.g. alternative lengthening of telomeres, ATRX/DAXX loss) have been independently validated. Additionally, recent transcriptomic and epigenetic studies focusing on endocrine differentiation have identified PanNET subtypes that display similarities to either α- or β-cells and differ in clinical outcomes. Thus, future prospective studies that incorporate genomic and epigenetic biomarkers are warranted and have translational potential for individualized therapeutic and surveillance strategies. |
| قاعدة البيانات: |
Supplemental Index |
