Correlation between contrast enhancement on intraoperative magnetic resonance imaging and histopathology in glioblastoma
| العنوان: | Correlation between contrast enhancement on intraoperative magnetic resonance imaging and histopathology in glioblastoma |
|---|---|
| المؤلفون: | J. J. Van Overbeeke, Olaf E. M. G. Schijns, Martin Lammens, Pieter Wesseling, H. van Santbrink, Pieter L. Kubben, M.P. Ter Laak-Poort |
| المساهمون: | Pathology, CCA - Disease profiling |
| المصدر: | Kubben, P L, Wesseling, P, Lammens, M, Schijns, O E M G, Ter Laak-Poort, M P, van Overbeeke, J J & van Santbrink, H 2012, ' Correlation between contrast enhancement on intraoperative magnetic resonance imaging and histopathology in glioblastoma ', Surgical Neurology International, vol. 3, 158 . https://doi.org/10.4103/2152-7806.105097Test Surgical Neurology International, 3, 158-158 Surgical Neurology International, 3, 1, pp. 158-158 Surgical Neurology International, 3:158. Medknow Publications and Media Pvt. Ltd Surgical Neurology International |
| بيانات النشر: | Scientific Scholar, 2012. |
| سنة النشر: | 2012 |
| مصطلحات موضوعية: | Pathology, medicine.medical_specialty, Interventional magnetic resonance imaging, medicine.medical_treatment, Gadolinium, chemistry.chemical_element, Biopsy, Medicine, GeneralLiterature_REFERENCE(e.g.,dictionaries,encyclopedias,glossaries), neuropathology, medicine.diagnostic_test, neurooncology, business.industry, intraoperative magnetic resonance imaging, Neurooncology, Magnetic resonance imaging, Translational research Tissue engineering and pathology [ONCOL 3], Radiation therapy, Image-guided surgery, chemistry, Original Article, Surgery, Histopathology, Neurology (clinical), Glioblastoma, image guided surgery, business, Nuclear medicine |
| الوصف: | Object: Glioblastoma is a highly malignant brain tumor, for which standard treatment consists of surgery, radiotherapy, and chemotherapy. Increasing extent of tumor resection (EOTR) is associated with prolonged survival. Intraoperative magnetic resonance imaging (iMRI) is used to increase EOTR, based on contrast enhanced MR images. The correlation between intraoperative contrast enhancement and tumor has not been studied systematically. Methods: For this prospective cohort study, we recruited 10 patients with a supratentorial brain tumor suspect for a glioblastoma. After initial resection, a 0.15 Tesla iMRI scan was made and neuronavigation-guided biopsies were taken from the border of the resection cavity. Scores for gadolinium-based contrast enhancement on iMRI and for tissue characteristics in histological slides of the biopsies were used to calculate correlations (expressed in Kendall's tau). Results: A total of 39 biopsy samples was available for further analysis. Contrast enhancement was significantly correlated with World Health Organization (WHO) grade (tau 0.50), vascular changes (tau 0.53), necrosis (tau 0.49), and increased cellularity (tau 0.26). Specificity of enhancement patterns scored as “thick linear” and “tumor-like” for detection of (high grade) tumor was 1, but decreased to circa 0.75 if “thin linear” enhancement was included. Sensitivity for both enhancement patterns varied around 0.39-0.48 and 0.61-0.70, respectively. Conclusions: Presence of intraoperative contrast enhancement is a good predictor for presence of tumor, but absence of contrast enhancement is a bad predictor for absence of tumor. The use of gadolinium-based contrast enhancement on iMRI to maximize glioblastoma resection should be evaluated against other methods to increase resection, like new contrast agents, other imaging modalities, and “functional neurooncology” – an approach to achieve surgical resection guided by functional rather than oncological-anatomical boundaries. |
| وصف الملف: | application/pdf |
| تدمد: | 2152-7806 |
| الوصول الحر: | https://explore.openaire.eu/search/publication?articleId=doi_dedup___::0f07f1423476bcdeac147400cfcb0feeTest https://doi.org/10.4103/2152-7806.105097Test |
| حقوق: | OPEN |
| رقم الانضمام: | edsair.doi.dedup.....0f07f1423476bcdeac147400cfcb0fee |
| قاعدة البيانات: | OpenAIRE |
| تدمد: | 21527806 |
|---|