Shared genetic susceptibility to ischemic stroke and coronary artery disease: a genome-wide analysis of common variants
| العنوان: | Shared genetic susceptibility to ischemic stroke and coronary artery disease: a genome-wide analysis of common variants |
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| المؤلفون: | Dichgans, M., Malik, R., Konig, I. R., Rosand, J., Clarke, R., Gretarsdottir, S., Thorleifsson, G., Mitchell, B. D., Assimes, T. L., Levi, C., O'Donnell, C. J., Fornage, M., Thorsteinsdottir, U., Psaty, B. M., Hengstenberg, C., Seshadri, S., Erdmann, J., Bis, J. C., Peters, A., Boncoraglio, G. B., Marz, W., Meschia, J. F., Kathiresan, S., Ikram, M. A., McPherson, R., Stefansson, K., Sudlow, C., Reilly, M. P., Thompson, J. R., Sharma, P., Hopewell, J. C., Chambers, J. C., Watkins, H., Rothwell, P. M., Roberts, R., Markus, H. S., Samani, N. J., Farrall, M., Schunkert, H., Gschwendtner, A., Bevan, S., Chen, Y.-C., DeStefano, A. L., Parati, E. A., Quertermous, T., Ziegler, A., Boerwinkle, E., Holm, H., Fischer, M., Kessler, T., Willenborg, C., Laaksonen, R., Voight, B. F., Stewart, A. F. R., Rader, D. J., Hall, A. S., Kooner, J. S. |
| المساهمون: | Stroke and Dementia Research, Klinikum der Universität München, Ludwig-Maximilians-Universität, Munich, Germany (M.D., R. Malik), Munich Cluster for Systems Neurology (SyNergy), Munich, Germany (M.D.), Institut für Medizinische Biometrie und Statistik (I.R.K.), and Institut für integrative und experimentelle Genomik (J.E.), Universität zu Lübeck, Lübeck, Germany, Universitätsklinikum Schleswig-Holstein, Campus Lübeck, Germany (I.R.K.), Department of Neurology and Center for Human Genetic Research (J.R.), and Cardiology Division (C.J.O.D.), Massachusetts General Hospital, Boston, Harvard Medical School, Boston, MA (J.R.), Program in Medical and Population Genetics (J.R.), and Program in Medical and Population Genetics (S.K.), Broad Institute of Harvard and MIT, Cambridge, MA, Clinical Trial Service Unit and Epidemiological Studies Unit (R.C., J.C.H.), Wellcome Trust Centre for Human Genetics (H.W., M. Farrall), Department of Cardiovascular Medicine (M. Farrall), and Stroke Prevention Research Unit, Nuffield Department of Clinical Neuroscience (P.M.R.), John Radcliffe Hospital, University of Oxford, Oxford, United Kingdom, deCODE Genetics, Reykjavik, Iceland (S.G., G.T., U.T., K.S.), Department of Medicine, University of Maryland School of Medicine, Baltimore (B.D.M.), Department of Medicine, Stanford University School of Medicine, Stanford, CA (T.L.A.), Center for Translational Neuroscience and Mental Health Research, University of Newcastle, New South Wales, Australia (C.L.), Hunter Medical Research Institute, New South Wales, Australia (C.L.), National Heart, Lung and Blood Institute and NHLBI's Framingham Heart Study, MA (C.J.O.D., S.S.), University of Texas Health Science Center at Houston (M. Fornage), Cardiovascular Health Research Unit, Department of Epidemiology (B.M.P.), Department of Medicine (B.M.P.), Department of Health Services (B.M.P.), and Cardiovascular Health Research Unit, Department of Medicine (J.C.B.), University, Radiology & Nuclear Medicine |
| المصدر: | Stroke; Vol 45 Stroke, 45(1), 24-36. Lippincott Williams & Wilkins |
| سنة النشر: | 2014 |
| مصطلحات موضوعية: | medicine.medical_specialty, Multifunction cardiogram, Áhættuþættir, Genome-wide association study, Coronary Artery Disease, Polymorphism, Single Nucleotide, Article, Brain Ischemia, Coronary artery disease, 03 medical and health sciences, 0302 clinical medicine, Heilablóðfall, Polymorphism (computer science), Risk Factors, Internal medicine, medicine, Genetic predisposition, Humans, Genetic Predisposition to Disease, Stroke, 030304 developmental biology, Advanced and Specialized Nursing, 0303 health sciences, business.industry, Kransæðasjúkdómar, Reproducibility of Results, Heritability, Arfgengi, medicine.disease, Phenotype, Meta-analysis, Data Interpretation, Statistical, Cardiology, Neurology (clinical), Cardiology and Cardiovascular Medicine, business, 030217 neurology & neurosurgery, Genome-Wide Association Study |
| الوصف: | To access publisher's full text version of this article, please click on the hyperlink in Additional Links field or click on the hyperlink at the top of the page marked Files. This article is open access. Ischemic stroke (IS) and coronary artery disease (CAD) share several risk factors and each has a substantial heritability. We conducted a genome-wide analysis to evaluate the extent of shared genetic determination of the two diseases. Genome-wide association data were obtained from the METASTROKE, Coronary Artery Disease Genome-wide Replication and Meta-analysis (CARDIoGRAM), and Coronary Artery Disease (C4D) Genetics consortia. We first analyzed common variants reaching a nominal threshold of significance (P |
| اللغة: | English |
| تدمد: | 1524-4628 0039-2499 2682-0110 |
| الوصول الحر: | https://explore.openaire.eu/search/publication?articleId=doi_dedup___::5e8c805c3e2f4a2614fc1aca5491d25aTest http://ora.ox.ac.uk/objects/uuid:2338b096-e57b-4619-b120-4563f0d0c71aTest |
| حقوق: | OPEN |
| رقم الانضمام: | edsair.doi.dedup.....5e8c805c3e2f4a2614fc1aca5491d25a |
| قاعدة البيانات: | OpenAIRE |
| تدمد: | 15244628 00392499 26820110 |
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