Confounding of Cerebral Blood Flow Velocity by Blood Pressure During Breath Holding or Hyperventilation in Transient Ischemic Attack or Stroke
| العنوان: | Confounding of Cerebral Blood Flow Velocity by Blood Pressure During Breath Holding or Hyperventilation in Transient Ischemic Attack or Stroke |
|---|---|
| المؤلفون: | Alastair J.S. Webb, Sara Mazzucco, Oxford Vascular Study Phenotyped Cohort, Linxin Li, Matteo Paolucci, Peter M. Rothwell |
| المصدر: | Stroke PubMed Central |
| بيانات النشر: | Lippincott Williams & Wilkins, 2019. |
| سنة النشر: | 2019 |
| مصطلحات موضوعية: | Male, medicine.medical_specialty, Middle Cerebral Artery, Ultrasonography, Doppler, Transcranial, Original Contributions, Clinical Sciences, Breath Holding, 03 medical and health sciences, 0302 clinical medicine, Internal medicine, medicine.artery, Hyperventilation, medicine, Humans, Stroke, 030304 developmental biology, Aged, Advanced and Specialized Nursing, 0303 health sciences, business.industry, leukoaraiosis, blood pressure, Carbon Dioxide, Middle Aged, medicine.disease, stroke, 3. Good health, Transcranial Doppler, Stenosis, Mean blood pressure, Blood pressure, Cerebral blood flow, Ischemic Attack, Transient, Cerebrovascular Circulation, Middle cerebral artery, Cardiology, ComputingMethodologies_DOCUMENTANDTEXTPROCESSING, Female, Neurology (clinical), medicine.symptom, linear models, Cardiology and Cardiovascular Medicine, business, 030217 neurology & neurosurgery, Blood Flow Velocity |
| الوصف: | Supplemental Digital Content is available in the text. Background and Purpose— Breath holding (BH) and hyperventilation are used to assess abnormal cerebrovascular reactivity, often in relation to severity of small vessel disease and risk of stroke with carotid stenosis, but responses may be confounded by blood pressure (BP) changes. We compared effects of BP and end-tidal carbon dioxide (etCO2) on middle cerebral artery mean flow velocity (MFV) in consecutive transient ischemic attack and minor stroke patients. Methods— In the population-based, prospective OXVASC (Oxford Vascular Study) phenotyped cohort, change in MFV on transcranial Doppler ultrasound (ΔMFV, DWL-DopplerBox), beat-to-beat BP (Finometer), and etCO2 was measured during 30 seconds of BH or hyperventilation. Two blinded reviewers independently assessed recording quality. Dependence of ΔMFV on ΔBP and ΔetCO2 was determined by general linear models, stratified by quartiles. Results— Four hundred eighty-eight of 602 (81%) patients with adequate bone windows had high-quality recordings, more often in younger participants (64.6 versus 68.7 years; P |
| اللغة: | English |
| تدمد: | 1524-4628 0039-2499 |
| الوصول الحر: | https://explore.openaire.eu/search/publication?articleId=doi_dedup___::167d545d0cd467b93797e88757224933Test http://europepmc.org/articles/PMC7004447Test |
| حقوق: | OPEN |
| رقم الانضمام: | edsair.doi.dedup.....167d545d0cd467b93797e88757224933 |
| قاعدة البيانات: | OpenAIRE |
| تدمد: | 15244628 00392499 |
|---|