دورية أكاديمية
Changes of Bone Turnover Markers in Long Bone Nonunions Treated with a Regenerative Approach
| العنوان: | Changes of Bone Turnover Markers in Long Bone Nonunions Treated with a Regenerative Approach |
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| المؤلفون: | Donatella Granchi, Enrique Gómez-Barrena, Markus Rojewski, Philippe Rosset, Pierre Layrolle, Benedetta Spazzoli, Davide Maria Donati, Gabriela Ciapetti |
| المصدر: | Stem Cells International, Vol 2017 (2017) |
| بيانات النشر: | Hindawi Limited, 2017. |
| سنة النشر: | 2017 |
| المجموعة: | LCC:Internal medicine |
| مصطلحات موضوعية: | Internal medicine, RC31-1245 |
| الوصف: | In this clinical trial, we investigated if biochemical bone turnover markers (BTM) changed according to the progression of bone healing induced by autologous expanded MSC combined with a biphasic calcium phosphate in patients with delayed union or nonunion of long bone fractures. Bone formation markers, bone resorption markers, and osteoclast regulatory proteins were measured by enzymatic immunoassay before surgery and after 6, 12, and 24 weeks. A satisfactory bone healing was obtained in 23 out of 24 patients. Nine subjects reached a good consolidation already at 12 weeks, and they were considered as the “early consolidation” group. We found that bone-specific alkaline phosphatase (BAP), C-terminal propeptide of type I procollagen (PICP), and beta crosslaps collagen (CTX) changed after the regenerative treatment, BAP and CTX correlated to the imaging results collected at 12 and 24 weeks, and BAP variation along the healing course differed in patients who had an “early consolidation.” A remarkable decrease in BAP and PICP was observed at all time points in a single patient who experienced a treatment failure, but the predictive value of BTM changes cannot be determined. Our findings suggest that BTM are promising tools for monitoring cell therapy efficacy in bone nonunions, but studies with larger patient numbers are required to confirm these preliminary results. |
| نوع الوثيقة: | article |
| وصف الملف: | electronic resource |
| اللغة: | English |
| تدمد: | 1687-966X 1687-9678 |
| العلاقة: | https://doaj.org/toc/1687-966XTest; https://doaj.org/toc/1687-9678Test |
| DOI: | 10.1155/2017/3674045 |
| الوصول الحر: | https://doaj.org/article/8f1d2634f1f043f4ae2fc0d09e13d6ceTest |
| رقم الانضمام: | edsdoj.8f1d2634f1f043f4ae2fc0d09e13d6ce |
| قاعدة البيانات: | Directory of Open Access Journals |
Full Text Finder | تدمد: | 1687966X 16879678 |
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| DOI: | 10.1155/2017/3674045 |