التفاصيل البيبلوغرافية
| العنوان: |
Cancer Stem Cell-Specific Scavenger Receptor 36 Drives Glioblastoma Progression. |
| المؤلفون: |
Hale, James S., Otvos, Balint, Sinyuk, Maksim, Alvarado, Alvaro G., Hitomi, Masahiro, Stoltz, Kevin, Wu, Qiulian, Flavahan, William, Levison, Bruce, Johansen, Mette L., Schmitt, David, Neltner, Janna M., Huang, Ping, Ren, Bin, Sloan, Andrew E., Silverstein, Roy L., Gladson, Candece L., DiDonato, Joseph A., Brown, J. Mark, McIntyre, Thomas |
| المصدر: |
Stem Cells; Jul2014, Vol. 32 Issue 7, p1746-1758, 13p |
| مصطلحات موضوعية: |
CANCER stem cells, SCAVENGER receptors (Biochemistry), CD36 antigen, GLIOBLASTOMA multiforme, XENOGRAFTS, ENDOTHELIAL cells, MACROPHAGES, MICROGLIA |
| مستخلص: |
Glioblastoma (GBM) contains a self-renewing, tumorigenic cancer stem cell (CSC) population which contributes to tumor propagation and therapeutic resistance. While the tumor microenvironment is essential to CSC self-renewal, the mechanisms by which CSCs sense and respond to microenvironmental conditions are poorly understood. Scavenger receptors are a broad class of membrane receptors well characterized on immune cells and instrumental in sensing apoptotic cellular debris and modified lipids. Here, we provide evidence that CSCs selectively use the scavenger receptor CD36 to promote their maintenance using patient-derived CSCs and in vivo xenograft models. CD36 expression was observed in GBM cells in addition to previously described cell types including endothelial cells, macrophages, and microglia. CD36 was enriched in CSCs and was able to functionally distinguish self-renewing cells. CD36 was coexpressed with integrin alpha 6 and CD133, previously described CSC markers, and CD36 reduction resulted in concomitant loss of integrin alpha 6 expression, self-renewal, and tumor initiation capacity. We confirmed oxidized phospholipids, ligands of CD36, were present in GBM and found that the proliferation of CSCs, but not non-CSCs, increased with exposure to oxidized low-density lipoprotein. CD36 was an informative biomarker of malignancy and negatively correlated to patient prognosis. These results provide a paradigm for CSCs to thrive by the selective enhanced expression of scavenger receptors, providing survival, and metabolic advantages. S tem C ells 2014;32:1746-1758 [ABSTRACT FROM AUTHOR] |
|
Copyright of Stem Cells is the property of Oxford University Press / USA and its content may not be copied or emailed to multiple sites or posted to a listserv without the copyright holder's express written permission. However, users may print, download, or email articles for individual use. This abstract may be abridged. No warranty is given about the accuracy of the copy. Users should refer to the original published version of the material for the full abstract. (Copyright applies to all Abstracts.) |
| قاعدة البيانات: |
Complementary Index |
Full Text Finder