دورية أكاديمية
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Generation of induced pluripotent stem cell line LNDWCHi001-A from a patient with early-onset Parkinson’s disease carrying the homozygous c.1898C > T (p. A633V) mutation in the PLA2G6 gene

التفاصيل البيبلوغرافية
العنوان: Generation of induced pluripotent stem cell line LNDWCHi001-A from a patient with early-onset Parkinson’s disease carrying the homozygous c.1898C > T (p. A633V) mutation in the PLA2G6 gene
المؤلفون: Jingxuan Huang, Qirui Jiang, Dejiang Pang, Yujiao Yu, Yiyuan Cui, Chunyu Li, Huifang Shang
المصدر: Stem Cell Research, Vol 75, Iss , Pp 103305- (2024)
بيانات النشر: Elsevier, 2024.
سنة النشر: 2024
المجموعة: LCC:Biology (General)
مصطلحات موضوعية: Biology (General), QH301-705.5
الوصف: A variant of the phospholipase A2 group VI gene (PLA2G6, PARK14) has been found to cause early-onset Parkinson’s disease (EOPD). In this study, we reprogrammed peripheral blood mononuclear cells from a 39-year-old patient with EOPD carrying a homozygous PLA2G6 mutation c.1898C > T (p. A633V) to generate the human induced pluripotent stem cell line LNDWCHi001-A. This cell line was identified based on pluripotent markers and displayed differentiation capacity, providing an essential model for studying the pathogenesis of EOPD and drug screening.
نوع الوثيقة: article
وصف الملف: electronic resource
اللغة: English
تدمد: 1873-5061
العلاقة: http://www.sciencedirect.com/science/article/pii/S1873506124000035Test; https://doaj.org/toc/1873-5061Test
DOI: 10.1016/j.scr.2024.103305
الوصول الحر: https://doaj.org/article/33a5c2b53f4f4cae8bfb783b0989e1cbTest
رقم الانضمام: edsdoj.33a5c2b53f4f4cae8bfb783b0989e1cb
قاعدة البيانات: Directory of Open Access Journals
الوصف
تدمد:18735061
DOI:10.1016/j.scr.2024.103305