The effects of short-term combined exercise training on telomere length in obese women: a prospective, interventional study
| العنوان: | The effects of short-term combined exercise training on telomere length in obese women: a prospective, interventional study |
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| المؤلفون: | Julio Sérgio Marchini, Ellen Cristini de Freitas, Flávia Giolo De Carvalho, Carla Barbosa Nonino, Camila Fernanda Cunha Brandao, Rocio San Martin, Márcia Varella Morandi Junqueira-Franco, Natália Yumi Noronha, Carolina Ferreira Nicoletti |
| المصدر: | Sports Medicine-Open Repositório Institucional da USP (Biblioteca Digital da Produção Intelectual) Universidade de São Paulo (USP) instacron:USP |
| بيانات النشر: | Springer International Publishing, 2020. |
| سنة النشر: | 2020 |
| مصطلحات موضوعية: | Senescence, medicine.medical_specialty, Waist, Sports medicine, Physical fitness, Physical Therapy, Sports Therapy and Rehabilitation, 030204 cardiovascular system & hematology, 03 medical and health sciences, 0302 clinical medicine, Internal medicine, medicine, Aerobic exercise, Orthopedics and Sports Medicine, 030212 general & internal medicine, Original Research Article, Obesity, Telomere length, business.industry, Physical Activity, Circumference, medicine.disease, Telomere, Endocrinology, TELÔMERO, Combined exercise training, Waist circumference, business |
| الوصف: | Background Telomere length is inversely associated with the senescence and aging process. Parallelly, obesity can promote telomere shortening. Evidence suggests that physical activity may promote telomere elongation. Objective This study’s objective is to evaluate the effects of combined exercise training on telomere length in obese women. Design and Methods Twenty pre-menopausal women (BMI 30–40 kg/m2, 20–40 years) submitted to combined training (strength and aerobic exercises), but only 13 finished the protocol. Each exercise session lasted 55 min/day, three times a week, throughout 8 weeks. Anthropometric data, body composition, physical performance (Vo2max), and 8-h fasting blood samples were taken before and after 8 weeks of training. Leukocyte DNA was extracted for telomere length by RT-qPCR reaction, using the 2−ΔΔCt methodology. Results After the training intervention, significant differences (p < 0.05) were observed in telomere length (respectively before and after, 1.03 ± 0.04 to 1.07 ± 0.04 T/S ratio), fat-free mass (46 ± 7 to 48 ± 5 kg), Vo2max (35 ± 3 to 38 ± 3 ml/kg/min), and waist circumference (96 ± 8 to 90 ± 6 cm). In addition, an inverse correlation between waist circumference and telomere length was found, before (r = − 0.536, p = 0.017) and after (r = − 0.655, p = 0.015) exercise training. Conclusion Combined exercise promoted leukocyte telomere elongation in obese women. Besides, the data suggested that greater waist circumference may predict shorter telomere length. Clinical Trial Registration ClinicalTrails.gov, NCT03119350. Retrospectively registered on 18 April 2017 |
| اللغة: | English |
| تدمد: | 2198-9761 2199-1170 |
| الوصول الحر: | https://explore.openaire.eu/search/publication?articleId=doi_dedup___::328678f4022bf3a3e22f1b86b920d62bTest http://europepmc.org/articles/PMC6965549Test |
| حقوق: | OPEN |
| رقم الانضمام: | edsair.doi.dedup.....328678f4022bf3a3e22f1b86b920d62b |
| قاعدة البيانات: | OpenAIRE |
| تدمد: | 21989761 21991170 |
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