التفاصيل البيبلوغرافية
| العنوان: |
mTORC inhibition in the development and lifespan on Vanessa cardui. |
| المؤلفون: |
Mills, Cheyanne, Kee, Lynn |
| المصدر: |
Southeastern Biology; Jan-Dec2021, Vol. 68 Issue 1-4, p56-57, 2p |
| مصطلحات موضوعية: |
PAINTED lady (Insect), MTOR inhibitors, RAPAMYCIN, BUTTERFLIES, CATERPILLARS |
| مستخلص: |
The mechanistic target of rapamycin (mTOR) is a kinase that is conserved from yeast to mice to humans. mTOR functions in integrating signals to control cell and organismal growth, metabolism and ageing. Rapamycin, an inhibitor of mTOR extends the lifespan of many organisms, including worms, flies and mice. In this study, we investigated the effect of rapamycin on the development of Vanessa cardui, commonly known as painted lady butterflies. We observed that V. cardui caterpillars that have been fed rapamycin have a decreased growth rate and larval size. We also report that rapamycin fed caterpillars take a longer time to form chrysalis and do not hatch out of the chrysalis. These findings suggest that the butterflies cannot hatch due to impaired or delayed wing development. Future studies will investigate the effect of rapamycin treatment on mTOR target proteins. [ABSTRACT FROM AUTHOR] |
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| قاعدة البيانات: |
Complementary Index |
