Engineered Ferritin Nanoparticles for the Bioluminescence Tracking of Nanodrug Delivery in Cancer
| العنوان: | Engineered Ferritin Nanoparticles for the Bioluminescence Tracking of Nanodrug Delivery in Cancer |
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| المؤلفون: | Laura Marongiu, Francesca Mingozzi, Lucia Salvioni, Veronica Tinelli, Luisa Fiandra, Michela Bellini, Michael S. Christodoulou, Miriam Colombo, Davide Prosperi, Alberto Visioli, Benedetta Riva, Maria Antonietta Rizzuto, Gianni Frascotti, Daniele Passarella |
| المساهمون: | Bellini, M, Riva, B, Tinelli, V, Rizzuto, M, Salvioni, L, Colombo, M, Mingozzi, F, Visioli, A, Marongiu, L, Frascotti, G, Christodoulou, M, Passarella, D, Prosperi, D, Fiandra, L |
| المصدر: | Small. 16:2001450 |
| بيانات النشر: | Wiley, 2020. |
| سنة النشر: | 2020 |
| مصطلحات موضوعية: | Transferrin receptor, 02 engineering and technology, 010402 general chemistry, 01 natural sciences, Biomaterials, Drug Delivery Systems, In vivo, Cell Line, Tumor, Neoplasms, Humans, Bioluminescence, General Materials Science, Luciferase, apoferritin nanoparticle, self-immolative linker, tumor targeting, Chemistry, General Chemistry, luciferase/luciferin, 021001 nanoscience & nanotechnology, nanomedicine, Luciferin, 0104 chemical sciences, Apoferritins, Cancer cell, Drug delivery, Biophysics, Nanoparticles, Nanomedicine, 0210 nano-technology, Biotechnology |
| الوصف: | The identification of a highly sensitive method to check the delivery of administered nanodrugs into the tumor cells is a crucial step of preclinical studies aimed to develop new nanoformulated cures, since it allows the real therapeutic potential of these devices to be forecast. In the present work, the ability of an H-ferritin (HFn) nanocage, already investigated as a powerful tool for cancer therapy thanks to its ability to actively interact with the transferrin receptor 1, to act as an efficient probe for the monitoring of nanodrug delivery to tumors is demonstrated. The final formulation is a bioluminescent nanoparticle, where the luciferin probe is conjugated on nanoparticle surface by means of a disulfide containing linker (Luc-linker@HFn) which is subjected to glutathione-induced cyclization in tumor cell cytoplasm. The prolonged imaging of luciferase+ tumor models, demonstrated by an in vitro and an in vivo approach, associated with the prolonged release of luciferin into cancer cells by disulfide bridge reduction, clearly indicates the high efficiency of Luc-linker@HFn for drug delivery to the tumor tissues. |
| تدمد: | 1613-6829 1613-6810 |
| الوصول الحر: | https://explore.openaire.eu/search/publication?articleId=doi_dedup___::cc35612c3919d0605e5c3efb65e28b60Test https://doi.org/10.1002/smll.202001450Test |
| حقوق: | CLOSED |
| رقم الانضمام: | edsair.doi.dedup.....cc35612c3919d0605e5c3efb65e28b60 |
| قاعدة البيانات: | OpenAIRE |
| تدمد: | 16136829 16136810 |
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