Impact of concomitant obstructive sleep apnea on pulmonary involvement and main pulmonary artery diameter in adults with scleroderma
| العنوان: | Impact of concomitant obstructive sleep apnea on pulmonary involvement and main pulmonary artery diameter in adults with scleroderma |
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| المؤلفون: | Haner Direskeneli, Sait Karakurt, Yüksel Peker, Baran Balcan, Yasemin Yalcinkaya, Tugce Yakut |
| المساهمون: | Peker, Yüksel, Yakut, Tuğçe, Balcan, Baran, Karakurt, Sait, Direskeneli, Haner, Yalçınkaya, Yasemin, School of Medicine, Yakut, Tugce, Yalcinkaya, Yasemin, Peker, Yuksel, Peker, Yüksel (ORCID 0000-0001-9067-6538 & YÖK ID 234103), Koç University Hospital |
| المصدر: | Sleep and Breathing Sleep & Breathing = Schlaf & Atmung |
| بيانات النشر: | Springer Science and Business Media LLC, 2020. |
| سنة النشر: | 2020 |
| مصطلحات موضوعية: | Male, Pulmonary Fibrosis, Clinical neurology, Respiratory system, 030204 cardiovascular system & hematology, Scleroderma, Pulmonary function testing, 0302 clinical medicine, Medicine, Obstructive sleep apnea, Pulmonary involvement, Pulmonary hypertension, Sleep Apnea, Obstructive, Sleep apnea, Middle Aged, Respiratory Function Tests, DAYTIME SLEEPINESS, Cardiology, Female, Neurosciences, Neurology, Adult, medicine.medical_specialty, DISORDERS, Hypertension, Pulmonary, Pulmonary Artery, Skin Diseases, Young Adult, 03 medical and health sciences, Scleroderma, Limited, Internal medicine, Humans, COMPUTED-TOMOGRAPHY, COMMON, Aged, 030203 arthritis & rheumatology, HYPERTENSION, business.industry, Sleep Breathing Physiology and Disorders • Original Article, SYSTEMIC-SCLEROSIS, Odds ratio, medicine.disease, nervous system diseases, respiratory tract diseases, Cross-Sectional Studies, Otorhinolaryngology, Concomitant, Scleroderma, Diffuse, Neurology (clinical), Tomography, X-Ray Computed, business, Body mass index |
| الوصف: | Purpose: pulmonary involvement is common in adults with scleroderma. The effect of concomitant obstructive sleep apnea (OSA) on risk for pulmonary hypertension in scleroderma is unknown. An enlarged main pulmonary artery diameter (mPAD) derived from chest computer tomography (CT) is a useful predictor of pulmonary hypertension. We addressed the effect of OSA on pulmonary involvement and enlarged mPAD in adults with scleroderma. Methods: all participants underwent pulmonary function testing, carbon monoxide diffusion capacity, chest CT, and overnight sleep recording with home sleep apnea testing. OSA diagnosis was based on an apnea-hypopnea index (AHI) >= 15/h. Oxygen desaturation index (ODI) was also recorded. Scleroderma involvement of the lungs was defined as the Warrick score >= 7 based on the CT findings. Enlarged mPAD was defined as an mPAD >= 29 mm in men and >= 27 mm in women. Results: after exclusions, 62 patients (58 women) were included. OSA was found among 20 (32%), 17/42 (38%) in the limited cutaneous type, and 3/20 (15%) in the diffuse cutaneous type (p = 0.08). Scleroderma involvement of the lungs was observed in 40 participants (65% in OSA vs 64% in no-OSA; n.s.). Enlarged mPAD was measured in 16 participants, 10 of 20 (50%) in the OSA group and 6 of 17 (14%) in the no-OSA group (p = 0.003). OSA was associated with enlarged mPAD (odds ratio 4.7, 95% confidence interval 1.1-20.9; p = 0.042) independent of age, body mass index, and pulmonary involvement. There was a linear relationship between mPAD and AHI (r = 0.37; p = 0.003) as well as ODI (r = 0.41; p < 0.001). Conclusions: in this cohort, OSA was associated with risk for pulmonary hypertension independent of pulmonary involvement. These findings suggest that assessing the effect of therapy for concomitant OSA in patients with scleroderma is warranted. University of Gothenburg |
| وصف الملف: | pdf; application/pdf; text/academic publication |
| تدمد: | 1522-1709 1520-9512 |
| الوصول الحر: | https://explore.openaire.eu/search/publication?articleId=doi_dedup___::dd50b8cf3de49ae1f143c9c14e69e219Test https://doi.org/10.1007/s11325-020-02059-4Test |
| حقوق: | OPEN |
| رقم الانضمام: | edsair.doi.dedup.....dd50b8cf3de49ae1f143c9c14e69e219 |
| قاعدة البيانات: | OpenAIRE |
| تدمد: | 15221709 15209512 |
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