No elevation of serum adiponectin in OSA patients after continuous positive airway pressure treatment: a meta-analysis
| العنوان: | No elevation of serum adiponectin in OSA patients after continuous positive airway pressure treatment: a meta-analysis |
|---|---|
| المؤلفون: | Guangyue Qin, Tingyu Tang, Wenjuan Wu, Xiaoxi Zhou, Li Yang, Liang Gu, Tian Zhao, Zhijun Li |
| المصدر: | Sleep and Biological Rhythms. 14:287-293 |
| بيانات النشر: | Springer Science and Business Media LLC, 2016. |
| سنة النشر: | 2016 |
| مصطلحات موضوعية: | medicine.medical_specialty, Physiology, medicine.medical_treatment, Subgroup analysis, Cochrane Library, 03 medical and health sciences, 0302 clinical medicine, Physiology (medical), Internal medicine, medicine, 030212 general & internal medicine, Continuous positive airway pressure, Adiponectin, business.industry, medicine.disease, nervous system diseases, respiratory tract diseases, Obstructive sleep apnea, Neuropsychology and Physiological Psychology, Endocrinology, 030228 respiratory system, Neurology, Apnea–hypopnea index, Meta-analysis, business, Body mass index |
| الوصف: | It is reported that the level of serum adiponectin is closely associated with status of obstructive sleep apnea (OSA). However, the effect of continuous positive airway pressure (CPAP) on adiponectin concentration remains controversial. Therefore, the aim of study is to testify the hypothesis that there is a systematic elevation in serum adiponectin with CPAP. We reviewed relevant studies by searching Medline, Pubmed, Embase, and the Cochrane library from 2006 to 2014. Eligible studies which focused on effects of CPAP on adiponectin levels in OSA patients, were identified by two independent reviewers. RevMan and STATA software were utilized for data synthesis and analysis. Association between CPAP and adiponectin was evaluated by polled analysis, and subgroup analysis, basing on detection method, duration of CPAP, sample size, body mass index (BMI), apnea hypopnea index and regional distribution. In total 10 articles were enrolled into the meta-analysis. The results demonstrated that standardised mean difference of the adiponectin levels pre- and post-CPAP therapy was −0.04 (95 % CI −0.21 to 0.12), test for overall effect z = 0.49 (P = 0.62). Subgroup analysis showed that differences in detection method, duration of CPAP, sample size, BMI, OSA severity and regional distribution did not affect the results of polled analysis. The study demonstrated that there was no systematic change in serum adiponectin with CPAP in OSA patients. |
| تدمد: | 1479-8425 1446-9235 |
| الوصول الحر: | https://explore.openaire.eu/search/publication?articleId=doi_________::96b3329d2833d1ecbda39694ec29072dTest https://doi.org/10.1007/s41105-016-0057-7Test |
| حقوق: | CLOSED |
| رقم الانضمام: | edsair.doi...........96b3329d2833d1ecbda39694ec29072d |
| قاعدة البيانات: | OpenAIRE |
| تدمد: | 14798425 14469235 |
|---|