التفاصيل البيبلوغرافية
| العنوان: |
Immunophenotypes, apoptosis, and expression of Fas and Bcl-2 from peripheral blood lymphocytes in patients with secondary early syphilis. |
| المؤلفون: |
Fan, Yl-Ming1,2, Zeng, Wen-Jun1, Wu, Zhi-Hua1, Li, Shun-Fan1, Fan, Yi-Ming3 (AUTHOR) |
| المصدر: |
Sexually Transmitted Diseases. Apr2004, Vol. 31 Issue 4, p221-224. 4p. |
| مصطلحات موضوعية: |
*LYMPHOCYTES, *APOPTOSIS, *SYPHILIS, *T cells, *IMMUNE system, *CYTOMETRY |
| مستخلص: |
Objectives: Whether syphilis influences lymphocyte apoptosis has not been reported so far.Goal: The goals of this study were to determine whether syphilis influences lymphocyte apoptosis and to investigate the molecular mechanism of apoptosis.Study Design: Peripheral blood lymphocyte (PBL) immunophenotypes, apoptosis, and expression of Fas (CD95) and Bcl-2 were detected by flow cytometry in 33 patients with secondary early syphilis and 30 healthy subjects.Results: Compared with the control subjects, the percentage of CD4 T cells and the ratio of CD4:CD8 were significantly decreased, and that of CD8 T cells and the apoptotic rates of PBLs and CD4 T cells were obviously increased in syphilitic patients. Fas overexpression and Bcl-2 downexpression in the syphilitic group were observed in PBLs and CD4 cells but not in CD8 and CD19 cells.Conclusions: The increased apoptosis of PBLs and CD4 T cells by Fas-mediated death pathway and downexpression of Bcl-2 protein could account for immune dysfunction in secondary early syphilis, which is responsible for the incomplete clearance of Treponema pallidum from the lesions and the chronic infection. [ABSTRACT FROM AUTHOR] |
| قاعدة البيانات: |
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