Chlamydia trachomatis, herpes simplex virus 2, and human T-cell lymphotrophic virus type 1 are not associated with grade of cervical neoplasia in Jamaican colposcopy patients
التفاصيل البيبلوغرافية
العنوان:
Chlamydia trachomatis, herpes simplex virus 2, and human T-cell lymphotrophic virus type 1 are not associated with grade of cervical neoplasia in Jamaican colposcopy patients
Background: A few recent studies have suggested that other sexually transmitted infections may increase the likelihood of a human papillomavirus (HPV) infection progressing to high-grade cervical neoplasia and cancer. Goal: The goal was to assess whether exposures to Chlamydia trachomatis human T-cell lymphotrophic virus type 1 (HTLV-I) and/or human simplex virus type 2 (HSV-2) are greater in colposcopy patients with cervical intraepithelial neoplasia grade 3 or cancer (CIN3+) than in patients with low-grade cervical neoplasia (CIN1). Study Design: Sequential patients (n = 447) attending a colposcopy clinic in Kingston Jamaica a country with high cervical cancer rates and high HTLV-I prevalence were tested for (1) HPV DNA by L1 consensus primer (MY09/11) polymerase chain reaction assays (2) C trachomatis DNA by ligase chain reaction (3) C trachomatis antibodies by both microimmunofluorescence and a peptide (VS4) enzyme linked immunosorbent assay (ELISA) (4) HTLV-I antibodies by ELISA confirmed by western blotting and (5) HSV-2 antibodies by a recombinant HSV-2-specific ELISA. Odds ratios and 95% confidence intervals were estimated with use of multinomial logistic regression models. Results: HPV DNA detection was associated with grade of cervical neoplasia but other evaluated sexually transmitted infections were not. Conclusions: HTLV-I C trachomatis and/or HSV-2 were not associated with severity of cervical neoplasia in Jamaican women. (authors)
