Heterogeneity and plasticity of cancer-associated fibroblasts in the pancreatic tumor microenvironment
| العنوان: | Heterogeneity and plasticity of cancer-associated fibroblasts in the pancreatic tumor microenvironment |
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| المؤلفون: | Katarina D. Andini, Geert Kazemier, Godefridus J. Peters, Elisa Giovannetti, Lenka N.C. Boyd |
| المساهمون: | Surgery, Medical oncology laboratory, CCA - Cancer biology and immunology, CCA - Imaging and biomarkers, Amsterdam Gastroenterology Endocrinology Metabolism |
| المصدر: | Boyd, L N C, Andini, K D, Peters, G J, Kazemier, G & Giovannetti, E 2021, ' Heterogeneity and plasticity of cancer-associated fibroblasts in the pancreatic tumor microenvironment ', Seminars in Cancer Biology . https://doi.org/10.1016/j.semcancer.2021.03.006Test Seminars in Cancer Biology. Academic Press Inc. |
| سنة النشر: | 2020 |
| مصطلحات موضوعية: | 0301 basic medicine, Cancer Research, Pancreatic ductal adenocarcinoma, endocrine system diseases, Carcinogenesis, Aggressive disease, medicine.disease_cause, Metastasis, 03 medical and health sciences, 0302 clinical medicine, Cancer-Associated Fibroblasts, Pancreatic tumor, medicine, Tumor Microenvironment, Humans, Research evidence, Tumor microenvironment, business.industry, medicine.disease, digestive system diseases, Pancreatic Neoplasms, 030104 developmental biology, 030220 oncology & carcinogenesis, Cancer research, business, Carcinoma, Pancreatic Ductal |
| الوصف: | Pancreatic ductal adenocarcinoma (PDAC) is an aggressive disease with a notably poor prognosis, in urgent need of improved treatment strategies. The desmoplastic PDAC tumor microenvironment (TME), marked by a high concentration of cancer-associated-fibroblasts (CAFs), is a dynamic part of PDAC pathophysiology which occasions a variety of effects throughout the course of pancreatic tumorigenesis and disease evolution. A better understanding of the desmoplastic TME and CAF biology in particular, should provide new opportunities for improving therapeutics. That CAFs have a tumor-supportive role in oncogenesis is well known, yet research evidence has shown that CAFs also have tumor-repressive functions. In this review, we seek to clarify the intriguing heterogeneity and plasticity of CAFs and their ambivalent role in PDAC tumorigenesis and progression. Additionally, we provide recommendations to advance the implementation of CAF-directed PDAC care. An improved understanding of CAFs’ origins, spatial location, functional diversity, and marker determination, as well as CAF behavior during the course of PDAC progression and metastasis will provide essential knowledge for the future improvement of therapeutic strategies for patients suffering from PDAC. |
| تدمد: | 1096-3650 1044-579X |
| الوصول الحر: | https://explore.openaire.eu/search/publication?articleId=doi_dedup___::3d5456c023986787b966ada372e77348Test https://pubmed.ncbi.nlm.nih.gov/33737108Test |
| حقوق: | OPEN |
| رقم الانضمام: | edsair.doi.dedup.....3d5456c023986787b966ada372e77348 |
| قاعدة البيانات: | OpenAIRE |
| تدمد: | 10963650 1044579X |
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