Key biological processes driving metastatic spread of pancreatic cancer as identified by multi-omics studies
| العنوان: | Key biological processes driving metastatic spread of pancreatic cancer as identified by multi-omics studies |
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| المؤلفون: | H.W.M. van Laarhoven, Connie R. Jimenez, Elisa Giovannetti, Maarten F. Bijlsma, Geert Kazemier, T.Y.S. Le Large |
| المصدر: | Le Large, T Y S, Bijlsma, M F, Kazemier, G, van Laarhoven, H W M, Giovannetti, E & Jimenez, C R 2017, ' Key biological processes driving metastatic spread of pancreatic cancer as identified by multi-omics studies ', Seminars in Cancer Biology, vol. 44, pp. 153-169 . https://doi.org/10.1016/j.semcancer.2017.03.008Test Seminars in cancer biology (2017). doi:10.1016/j.semcancer.2017.03.008 info:cnr-pdr/source/autori:Le Large T.Y.S.; Bijlsma M.F.; Kazemier G.; van Laarhoven H.W.M.; Giovannetti E.; Jimenez C.R./titolo:Key biological processes driving metastatic spread of pancreatic cancer as identified by multi-omics studies/doi:10.1016%2Fj.semcancer.2017.03.008/rivista:Seminars in cancer biology/anno:2017/pagina_da:/pagina_a:/intervallo_pagine:/volume |
| بيانات النشر: | Elsevier BV, 2017. |
| سنة النشر: | 2017 |
| مصطلحات موضوعية: | 0301 basic medicine, Proteomics, Cancer Research, Biology, Adenocarcinoma, Malignancy, Bioinformatics, medicine.disease_cause, Metastasis, Pancreatic ductal adenocarcinoma, 03 medical and health sciences, 0302 clinical medicine, Pancreatic cancer, Genetics, medicine, Humans, Neoplasm Metastasis, Transcriptomics, Phosphoproteomics, medicine.disease, Prognosis, Primary tumor, digestive system diseases, Neoplasm Proteins, Gene Expression Regulation, Neoplastic, 030104 developmental biology, 030220 oncology & carcinogenesis, Cancer cell, Mutation, Cancer research, KRAS, Carcinoma, Pancreatic Ductal |
| الوصف: | Pancreatic ductal adenocarcinoma (PDAC) is an extremely aggressive malignancy, characterized by a high metastatic burden, already at the time of diagnosis. The metastatic potential of PDAC is one of the main reasons for the poor outcome next to lack of significant improvement in effective treatments in the last decade. Key mutated driver genes, such as activating KRAS mutations, are concordantly expressed in primary and metastatic tumors. However, the biology behind the metastatic potential of PDAC is not fully understood. Recently, large-scale omic approaches have revealed new mechanisms by which PDAC cells gain their metastatic potency. In particular, genomic studies have shown that multiple heterogeneous subclones reside in the primary tumor with different metastatic potential. The development of metastases may be correlated to a more mesenchymal transcriptomic subtype. However, for cancer cells to survive in a distant organ, metastatic sites need to be modulated into pre-metastatic niches. Proteomic studies identified the influence of exosomes on the Kuppfer cells in the liver, which could function to prepare this tissue for metastatic colonization. Phosphoproteomics adds an extra layer to the established omic techniques by unravelling key functional signaling. Future studies integrating results from these large-scale omic approaches will hopefully improve PDAC prognosis through identification of new therapeutic targets and patient selection tools. In this article, we will review the current knowledge on the biology of PDAC metastasis unravelled by large scale multi-omic approaches. |
| تدمد: | 1044-579X |
| DOI: | 10.1016/j.semcancer.2017.03.008 |
| الوصول الحر: | https://explore.openaire.eu/search/publication?articleId=doi_dedup___::39f946738e266020f164493ee81ce897Test |
| حقوق: | OPEN |
| رقم الانضمام: | edsair.doi.dedup.....39f946738e266020f164493ee81ce897 |
| قاعدة البيانات: | OpenAIRE |
| تدمد: | 1044579X |
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| DOI: | 10.1016/j.semcancer.2017.03.008 |