دورية أكاديمية
Promise and limits of the CellSearch platform for evaluating pharmacodynamics in circulating tumor cells.
| العنوان: | Promise and limits of the CellSearch platform for evaluating pharmacodynamics in circulating tumor cells. |
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| المؤلفون: | Wang, Lihua, Balasubramanian, Priya, Chen, Alice P, Kummar, Shivaani, Evrard, Yvonne A, Kinders, Robert J |
| المصدر: | Semin Oncol ; ISSN:1532-8708 ; Volume:43 ; Issue:4 |
| بيانات النشر: | Elsevier Science |
| سنة النشر: | 2016 |
| المجموعة: | PubMed Central (PMC) |
| مصطلحات موضوعية: | Assay validation, CTCs, Pharmacodynamics, Surrogate endpoint |
| الوصف: | Circulating tumor cells (CTCs), which are captured from blood with anti-epithelial cell adhesion molecule (EpCAM) antibodies, have established prognostic value in specific epithelial cancers, but less is known about their utility for assessing patient response to molecularly targeted agents via measurement of pharmacodynamic (PD) endpoints. We discuss the use of CellSearch (Janssen Diagnostics, LLC, Raritan, NJ) CTC isolation technology for monitoring PD response in early phase trials. We present representative data from three clinical trials with the poly(ADP-ribose) polymerase (PARP) inhibitor veliparib (ABT-888) suggesting that CTCs can be used to measure PD effects. However, while often leading to hypothesis-generating information, our experience points to the difficulty in obtaining sufficient EpCAM-expressing CTCs from patients with advanced disease to reach statistically significant conclusions about PD effects from each trial. Overall, the level of phenotypic heterogeneity observed in specimens from patients with advanced carcinomas suggests caution in the use of cell-surface differentiation marker-based methods for isolating CTCs. |
| نوع الوثيقة: | article in journal/newspaper review |
| اللغة: | English |
| العلاقة: | https://doi.org/10.1053/j.seminoncol.2016.06.004Test; https://pubmed.ncbi.nlm.nih.gov/27663478Test; https://www.ncbi.nlm.nih.gov/pmc/articles/PMC5074690Test/ |
| DOI: | 10.1053/j.seminoncol.2016.06.004 |
| الإتاحة: | https://doi.org/10.1053/j.seminoncol.2016.06.004Test https://pubmed.ncbi.nlm.nih.gov/27663478Test https://www.ncbi.nlm.nih.gov/pmc/articles/PMC5074690Test/ |
| حقوق: | Copyright © 2016 Elsevier Inc. All rights reserved. |
| رقم الانضمام: | edsbas.CBAC5B8D |
| قاعدة البيانات: | BASE |
| DOI: | 10.1053/j.seminoncol.2016.06.004 |
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