التفاصيل البيبلوغرافية
| العنوان: |
Periostin as a novel biomarker for postoperative recurrence of chronic rhinosinitis with nasal polyps. |
| المؤلفون: |
Ninomiya, Takahiro, Noguchi, Emiko, Haruna, Takenori, Hasegawa, Masayo, Yoshida, Takuto, Yamashita, Yukiko, Okano, Mitsuhiro, Yoshida, Naohiro, Haruna, Shinichi, Sakuma, Yasunori, Ohta, Shoichiro, Ono, Junya, Izuhara, Kenji, Okada, Masafumi, Kidoguchi, Masanori, Tokunaga, Takahiro, Okamoto, Masayuki, Kanno, Masafumi, Sakashita, Masafumi, Takabayashi, Tetsuji |
| المصدر: |
Scientific Reports; 7/30/2018, Vol. 8 Issue 1, p1-1, 1p |
| مستخلص: |
We previously reported that chronic rhinosinusitis with nasal polyps (CRSwNP) was subdivided into four chronic rhinosinusitis (CRS) subtypes using the JESREC scoring system. We sought to identify the gene expression profile and biomarkers related with CRSwNP by RNA-sequence. RNA-sequencing was performed to identify differentially expressed genes between nasal polyps (NPs) and inferior turbinate mucosa from 6 patients with CRSwNP, and subsequently, quantitative real-time PCR was performed to verify the results. ELISA was performed to identify possible biomarkers for postoperative recurrence. In the RNA-sequencing results, periostin (POSTN) expression was the highest in NP. We focused on POSTN and investigated the protein level of POSTN by immunohistochemistry and ELISA. POSTN was diffusely expressed in moderate and severe eosinophilic CRS using immunohistochemistry, and its staining pattern was associated with the severity of the phenotype of the CRSwNP (P < 0.05). There was a significant difference between the POSTN high/low groups for postoperative recurrence when the cutoff point was set at 115.5 ng/ml (P = 0.0072). Our data suggests that the protein expression level of POSTN was associated with the severity of CRSwNP, and serum POSTN can be a novel biomarker for postoperative recurrence of CRSwNP. [ABSTRACT FROM AUTHOR] |
|
Copyright of Scientific Reports is the property of Springer Nature and its content may not be copied or emailed to multiple sites or posted to a listserv without the copyright holder's express written permission. However, users may print, download, or email articles for individual use. This abstract may be abridged. No warranty is given about the accuracy of the copy. Users should refer to the original published version of the material for the full abstract. (Copyright applies to all Abstracts.) |
| قاعدة البيانات: |
Complementary Index |
Full Text Finder