Mitochondrial Haplogroup and the Risk of Acute Kidney Injury Following Cardiac Bypass Surgery
| العنوان: | Mitochondrial Haplogroup and the Risk of Acute Kidney Injury Following Cardiac Bypass Surgery |
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| المؤلفون: | John H. Dark, Simon Baudouin, Sarah Rowling, Mahesh Prabhu, Patrick F. Chinnery, Gavin Hudson, Timothy H.J. Goodship, Nigel S. Kanagasundaram |
| المصدر: | Scientific Reports Scientific Reports, Vol 9, Iss 1, Pp 1-9 (2019) |
| بيانات النشر: | Springer Science and Business Media LLC, 2019. |
| سنة النشر: | 2019 |
| مصطلحات موضوعية: | Adult, Male, 0301 basic medicine, medicine.medical_specialty, lcsh:Medicine, urologic and male genital diseases, Logistic regression, Article, Haplogroup, 03 medical and health sciences, Postoperative Complications, 0302 clinical medicine, Risk Factors, Interquartile range, Internal medicine, medicine, Humans, Coronary Artery Bypass, lcsh:Science, Aged, Aged, 80 and over, Multidisciplinary, business.industry, lcsh:R, Haplotype, Acute kidney injury, Acute Kidney Injury, Middle Aged, medicine.disease, Mitochondria, 030104 developmental biology, Haplotypes, Bypass surgery, Mutation, Population study, lcsh:Q, Female, business, 030217 neurology & neurosurgery, Human mitochondrial DNA haplogroup |
| الوصف: | Although mitochondrial dysfunction plays a key role in the pathophysiology of acute kidney injury (AKI), the influence of mitochondrial genetic variability in this process remains unclear. We explored the association between the risk of post-cardiac bypass AKI and mitochondrial haplotype – inherited mitochondrial genomic variations of potentially functional significance. Our single-centre study recruited consecutive patients prior to surgery. Exclusions included stage 5 CKD, non-Caucasian race and subsequent off-pump surgery. Haplogroup analysis allowed characterisation of the study population using the common mutations and by phylogenetic supergroup (WXI and HV). Chi-square tests for association allowed the identification of potential predictors of AKI for use in logistic regression analysis. AKI occurred in 12.8% of the study population (n = 881; male 69.6%, non-diabetic 78.5%, median (interquartile range) age 68.0 (61.0–75.0) years). The haplogroup profile comprised H (42.7%), J (12.1%), T (10.9%), U (14.4%) and K (7.6%). Although the regression model was statistically significant (χ2 = 95.483, p |
| تدمد: | 2045-2322 |
| الوصول الحر: | https://explore.openaire.eu/search/publication?articleId=doi_dedup___::6a067c4a8b0e405f34a2e600fb4d09c5Test https://doi.org/10.1038/s41598-018-37944-2Test |
| حقوق: | OPEN |
| رقم الانضمام: | edsair.doi.dedup.....6a067c4a8b0e405f34a2e600fb4d09c5 |
| قاعدة البيانات: | OpenAIRE |
| تدمد: | 20452322 |
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