التفاصيل البيبلوغرافية
| العنوان: |
Neuronally-enriched exosomal microRNA-27b mediates acute effects of ibuprofen on reward-related brain activity in healthy adults: a randomized, placebo-controlled, double-blind trial. |
| المؤلفون: |
Burrows, Kaiping, Figueroa-Hall, Leandra K., Kuplicki, Rayus, Stewart, Jennifer L., Alarbi, Ahlam M., Ramesh, Rajagopal, Savitz, Jonathan B., Teague, T. Kent, Risbrough, Victoria B., Paulus, Martin P. |
| المصدر: |
Scientific Reports; 1/17/2022, Vol. 12 Issue 1, p1-14, 14p |
| مصطلحات موضوعية: |
FUNCTIONAL magnetic resonance imaging, REWARD (Psychology), EXOSOMES, IBUPROFEN, MICRORNA |
| مستخلص: |
This double-blind, randomized, within-subjects design evaluated whether acute administration of an anti-inflammatory drug modulates neuron-specific, inflammation-modulating microRNAs linked to macroscopic changes in reward processing. Twenty healthy subjects (10 females, 10 males) underwent a functional magnetic resonance imaging scan while performing a monetary incentive delay (MID) task and provided blood samples after administration of placebo, 200 mg, or 600 mg of ibuprofen. Neuronally-enriched exosomal microRNAs were extracted from serum and sequenced. Results showed that: (1) 600 mg of ibuprofen exhibited higher miR-27b-3p, miR-320b, miR-23b and miR-203a-3p expression than placebo; (2) higher mir-27b-3p was associated with lower insula activation during MID loss anticipation; and (3) there was an inverse relationship between miR-27b-3p and MID gain anticipation in bilateral putamen during placebo, a pattern attenuated by both 200 mg and 600 mg of ibuprofen. These findings are consistent with the hypothesis that miR-27b could be an important messaging molecule that is associated with regulating the processing of positive or negative valenced information. [ABSTRACT FROM AUTHOR] |
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| قاعدة البيانات: |
Complementary Index |
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