التفاصيل البيبلوغرافية
| العنوان: |
Preemptive interleukin-6 blockade in patients with COVID-19. |
| المؤلفون: |
Guillén, Lucía1 (AUTHOR), Padilla, Sergio1 (AUTHOR), Fernández, Marta1 (AUTHOR), Agulló, Vanesa1 (AUTHOR), García, José Alberto1 (AUTHOR), Telenti, Guillermo1 (AUTHOR), García-Abellán, Javier1 (AUTHOR), Botella, Ángela1 (AUTHOR), Gutiérrez, Félix2,3 (AUTHOR) gutierrez_fel@gva.es, Masiá, Mar2,3 (AUTHOR) mmasia@umh.es |
| المصدر: |
Scientific Reports. 10/8/2020, Vol. 10 Issue 1, pN.PAG-N.PAG. 1p. |
| مصطلحات موضوعية: |
*INTERLEUKIN-6, *CYTOKINES, *TOCILIZUMAB, *COVID-19, *BIOMARKERS, *C-reactive protein |
| مستخلص: |
Excessive interleukin-6 signaling is a key factor contributing to the cytokine release syndrome implicated in clinical manifestations of COVID-19. Preliminary results suggest that tocilizumab, a humanized monoclonal anti-interleukin-6 receptor antibody, may be beneficial in severely ill patients, but no data are available on earlier stages of disease. An anticipated blockade of interleukin-6 might hypothetically prevent the catastrophic consequences of the overt cytokine storm. We evaluated early-given tocilizumab in patients hospitalized with COVID-19, and identified outcome predictors. Consecutive patients with initial Sequential-Organ-Failure-Assessment (SOFA) score < 3 fulfilling pre-defined criteria were treated with tocilizumab. Serial plasma biomarkers and nasopharyngeal swabs were collected. Of 193 patients admitted with COVID-19, 64 met the inclusion criteria. After tocilizumab, 49 (76.6%) had an early favorable response. Adjusted predictors of response were gender, SOFA score, neutrophil/lymphocyte ratio, Charlson comorbidity index and systolic blood pressure. At week-4, 56.1% of responders and 30% of non-responders had cleared the SARS-CoV-2 from nasopharynx. Temporal profiles of interleukin-6, C-reactive protein, neutrophil/lymphocyte ratio, NT-ProBNP, D-dimer, and cardiac-troponin-I differed according to tocilizumab response and discriminated final in-hospital outcome. No deaths or disease recurrences were observed. Preemptive therapy with tocilizumab was safe and associated with favorable outcomes in most patients. Biological and clinical markers predicted outcomes. [ABSTRACT FROM AUTHOR] |
| قاعدة البيانات: |
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