دورية أكاديمية
The relationship between cholinergic system brain structure and function in healthy adults and patients with mild cognitive impairment
| العنوان: | The relationship between cholinergic system brain structure and function in healthy adults and patients with mild cognitive impairment |
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| المؤلفون: | Jessica Peter, Isabella Mayer, Thomas Kammer, Lora Minkova, Jacob Lahr, Stefan Klöppel, Michel J. Grothe, Michael Orth |
| المصدر: | Scientific Reports, Vol 11, Iss 1, Pp 1-7 (2021) |
| بيانات النشر: | Nature Portfolio, 2021. |
| سنة النشر: | 2021 |
| المجموعة: | LCC:Medicine LCC:Science |
| مصطلحات موضوعية: | Medicine, Science |
| الوصف: | Abstract We assessed the structure–function relationship of the human cholinergic system and hypothesized that structural measures are associated with short-latency sensory afferent inhibition (SAI), an electrophysiological measure of central cholinergic signal transmission. Healthy volunteers (n = 36) and patients with mild cognitive impairment (MCI, n = 20) underwent median nerve SAI and 3T structural MRI to determine the volume of the basal forebrain and the thalamus. Patients with MCI had smaller basal forebrain (p 10% SAI) had more basal forebrain volume than non-responders (p = 0.004) or patients with MCI (p |
| نوع الوثيقة: | article |
| وصف الملف: | electronic resource |
| اللغة: | English |
| تدمد: | 2045-2322 |
| العلاقة: | https://doaj.org/toc/2045-2322Test |
| DOI: | 10.1038/s41598-021-95573-8 |
| الوصول الحر: | https://doaj.org/article/14a640e78bd34437a2d0eb958651d24eTest |
| رقم الانضمام: | edsdoj.14a640e78bd34437a2d0eb958651d24e |
| قاعدة البيانات: | Directory of Open Access Journals |
Full Text Finder | تدمد: | 20452322 |
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| DOI: | 10.1038/s41598-021-95573-8 |