Serum milk fat globule-EGF factor 8 (MFG-E8) as a diagnostic and prognostic biomarker in patients with hepatocellular carcinoma
| العنوان: | Serum milk fat globule-EGF factor 8 (MFG-E8) as a diagnostic and prognostic biomarker in patients with hepatocellular carcinoma |
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| المؤلفون: | Yosuke Osawa, Hironari Kawai, Masaki Mori, Yuzuru Sakamoto, Tomoyuki Akita, Taizo Mori, Hiroyoshi Doi, Takeshi Yoshida, Yunfei Ma, Tomonari Shimagaki, Akinobu Taketomi, Moto Fukai, Rikinari Hanayama, Tatsuya Kanto, Michitaka Matsuda, Junko Tanaka, Tomoharu Yoshizumi, Sachiyo Yoshio |
| المصدر: | Scientific Reports, Vol 9, Iss 1, Pp 1-12 (2019) Scientific Reports |
| بيانات النشر: | Nature Publishing Group, 2019. |
| سنة النشر: | 2019 |
| مصطلحات موضوعية: | 0301 basic medicine, Adult, Male, medicine.medical_specialty, Cirrhosis, Carcinoma, Hepatocellular, Hepatocellular carcinoma, medicine.medical_treatment, lcsh:Medicine, Gastroenterology, Article, Disease-Free Survival, Tumour biomarkers, 03 medical and health sciences, Liver disease, 0302 clinical medicine, Internal medicine, Preoperative Care, Carcinoma, Biomarkers, Tumor, Medicine, Humans, Prospective Studies, Prospective cohort study, lcsh:Science, Survival rate, Multidisciplinary, business.industry, Liver Neoplasms, lcsh:R, Area under the curve, Diagnostic markers, Middle Aged, medicine.disease, Milk Proteins, digestive system diseases, Neoplasm Proteins, Survival Rate, 030104 developmental biology, 030220 oncology & carcinogenesis, Antigens, Surface, Female, lcsh:Q, Hepatectomy, business |
| الوصف: | Current serum hepatocellular carcinoma (HCC) biomarkers are insufficient for early diagnosis. We aimed to clarify whether serum MFG-E8 can serve as a diagnostic or prognostic biomarker of HCC. Serum MFG-E8 levels of 282 HCC patients, who underwent primary hepatectomy, were examined by ELISA. We also quantified serum MFG-E8 levels in patients with chronic hepatitis (CH), liver cirrhosis (LC), as well as in healthy volunteers (HVs). Serum MFG-E8 levels were significantly lower in HCC patients than in HVs regardless of the etiology of liver disease (3.6 ± 0.1 vs 5.8 ± 0.2 ng/mL, p p) = 2.619 − 0.809 × serum MFG-E8 + 0.0226 × serum DCP) distinguished HCC patients from CH and LC patients with an area under the curve of 0.923, a sensitivity of 81.1%, and a specificity of 89.8%. Futhermore, low preoperative serum MFG-E8 was an independent predictor of poor overall survival. Thus, serum MFG-E8 could serve as a feasible diagnostic and prognostic biomarker for HCC. |
| اللغة: | English |
| تدمد: | 2045-2322 |
| الوصول الحر: | https://explore.openaire.eu/search/publication?articleId=doi_dedup___::b8cec126960e9fd1fe5973a677330568Test http://link.springer.com/article/10.1038/s41598-019-52356-6Test |
| حقوق: | OPEN |
| رقم الانضمام: | edsair.doi.dedup.....b8cec126960e9fd1fe5973a677330568 |
| قاعدة البيانات: | OpenAIRE |
| تدمد: | 20452322 |
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