دورية أكاديمية
Hodgkin lymphoma: hypodense lesions in mediastinal masses
| العنوان: | Hodgkin lymphoma: hypodense lesions in mediastinal masses |
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| المؤلفون: | Adrian Damek, Lars Kurch, Friedrich Christian Franke, Andishe Attarbaschi, Auke Beishuizen, Michaela Cepelova, Francesco Ceppi, Stephen Daw, Karin Dieckmann, Ana Fernández-Teijeiro, Tobias Feuchtinger, Jamie E. Flerlage, Alexander Fosså, Thomas W. Georgi, Dirk Hasenclever, Andrea Hraskova, Jonas Karlen, Tomasz Klekawka, Regine Kluge, Dieter Körholz, Judith Landman-Parker, Thierry Leblanc, Christine Mauz-Körholz, Markus Metzler, Jane Pears, Jonas Steglich, Anne Uyttebroeck, Dirk Vordermark, William Hamish Wallace, Walter Alexander Wohlgemuth, Dietrich Stoevesandt |
| المصدر: | Scientific Reports, Vol 14, Iss 1, Pp 1-9 (2024) |
| بيانات النشر: | Nature Portfolio, 2024. |
| سنة النشر: | 2024 |
| المجموعة: | LCC:Medicine LCC:Science |
| مصطلحات موضوعية: | Thymic cyst, Hypodense lesion, Hodgkin lymphoma, Tomography, X-ray computed, Medicine, Science |
| الوصف: | Abstract Hypodense volumes (HDV) in mediastinal masses can be visualized in a computed tomography scan in Hodgkin lymphoma. We analyzed staging CT scans of 1178 patients with mediastinal involvement from the EuroNet-PHL-C1 trial and explored correlations of HDV with patient characteristics, mediastinal tumor volume and progression-free survival. HDV occurred in 350 of 1178 patients (29.7%), typically in larger mediastinal volumes. There were different patterns in appearance with single lesions found in 243 patients (69.4%), multiple lesions in 107 patients (30.6%). Well delineated lesions were found in 248 cases (70.1%), diffuse lesions were seen in 102 cases (29.1%). Clinically, B symptoms occurred more often in patients with HDV (47.7% compared to 35.0% without HDV (p = 0.039)) and patients with HDV tended to be in higher risk groups. Inadequate overall early-18F-FDG-PET-response was strongly correlated with the occurrence of hypodense lesions (p 40 ml (n = 80) had a 5 year PFS of 79.6% compared to 89.7% (p = 0.01) in patients with HDV |
| نوع الوثيقة: | article |
| وصف الملف: | electronic resource |
| اللغة: | English |
| تدمد: | 2045-2322 |
| العلاقة: | https://doaj.org/toc/2045-2322Test |
| DOI: | 10.1038/s41598-024-64253-8 |
| الوصول الحر: | https://doaj.org/article/56fe25c1577a4d6ebc0c24ea6b216610Test |
| رقم الانضمام: | edsdoj.56fe25c1577a4d6ebc0c24ea6b216610 |
| قاعدة البيانات: | Directory of Open Access Journals |
Full Text Finder | تدمد: | 20452322 |
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| DOI: | 10.1038/s41598-024-64253-8 |