Multiple Genome Constellations of Similar and Distinct Influenza A Viruses Co-Circulate in Pigs During Epidemic Events
| العنوان: | Multiple Genome Constellations of Similar and Distinct Influenza A Viruses Co-Circulate in Pigs During Epidemic Events |
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| المؤلفون: | Claudia A. Muñoz-Zanzi, Andres Diaz, Montserrat Torremorell, Douglas Marthaler, Marie R. Culhane, Cesar Corzo, Srinand Sreevatsan |
| المصدر: | Scientific Reports, Vol 7, Iss 1, Pp 1-14 (2017) Scientific Reports |
| بيانات النشر: | Nature Publishing Group, 2017. |
| سنة النشر: | 2017 |
| مصطلحات موضوعية: | 0301 basic medicine, Swine, 030106 microbiology, Prevalence, lcsh:Medicine, Genome, Viral, Biology, medicine.disease_cause, Genome, Article, 03 medical and health sciences, Orthomyxoviridae Infections, Reassortant Viruses, Pandemic, Influenza A virus, medicine, Animals, Allele, Epidemics, lcsh:Science, Swine Diseases, Multidisciplinary, Transmission (medicine), Incidence (epidemiology), lcsh:R, Virology, 030104 developmental biology, lcsh:Q |
| الوصف: | Swine play a key role in the ecology and transmission of influenza A viruses (IAVs) between species. However, the epidemiology and diversity of swine IAVs is not completely understood. In this cohort study, we sampled on a weekly basis 132 3-week old pigs for 15 weeks. We found two overlapping epidemic events of infection in which most pigs (98.4%) tested PCR positive for IAVs. The prevalence rate of infection ranged between 0 and 86% per week and the incidence density ranged between 0 and 71 cases per 100 pigs-week. Three distinct influenza viral groups (VGs) replicating as a “swarm” of viruses were identified (swine H1-gamma, H1-beta, and H3-cluster-IV IAVs) and co-circulated at different proportions over time suggesting differential allele fitness. Furthermore, using deep genome sequencing 13 distinct viral genome constellations were differentiated. Moreover, 78% of the pigs had recurrent infections with IAVs closely related to each other or IAVs clearly distinct. Our results demonstrated the molecular complexity of swine IAVs during natural infection of pigs in which novel strains of IAVs with zoonotic and pandemic potential can emerge. These are key findings to design better health interventions to reduce the transmission of swine IAVs and minimize the public health risk. |
| اللغة: | English |
| تدمد: | 2045-2322 |
| الوصول الحر: | https://explore.openaire.eu/search/publication?articleId=doi_dedup___::f82bf9b4e517879887d2b4c066e2ba6cTest http://link.springer.com/article/10.1038/s41598-017-11272-3Test |
| حقوق: | OPEN |
| رقم الانضمام: | edsair.doi.dedup.....f82bf9b4e517879887d2b4c066e2ba6c |
| قاعدة البيانات: | OpenAIRE |
| تدمد: | 20452322 |
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