التفاصيل البيبلوغرافية
| العنوان: |
A system for bioelectronic delivery of treatment directed toward wound healing. |
| المؤلفون: |
Baniya, Prabhat, Tebyani, Maryam, Asefifeyzabadi, Narges, Nguyen, Tiffany, Hernandez, Cristian, Zhu, Kan, Li, Houpu, Selberg, John, Hsieh, Hao-Chieh, Pansodtee, Pattawong, Yang, Hsin-ya, Recendez, Cynthia, Keller, Gordon, Hee, Wan Shen, Aslankoohi, Elham, Isseroff, Roslyn Rivkah, Zhao, Min, Gomez, Marcella, Rolandi, Marco, Teodorescu, Mircea |
| المصدر: |
Scientific Reports; 11/20/2023, Vol. 13 Issue 1, p1-17, 17p |
| مصطلحات موضوعية: |
WOUND healing, EPOXY coatings, PRINTED circuits, ELECTRIC fields, CAPILLARY tubes, RAPID prototyping, LABORATORY mice |
| مستخلص: |
The development of wearable bioelectronic systems is a promising approach for optimal delivery of therapeutic treatments. These systems can provide continuous delivery of ions, charged biomolecules, and an electric field for various medical applications. However, rapid prototyping of wearable bioelectronic systems for controlled delivery of specific treatments with a scalable fabrication process is challenging. We present a wearable bioelectronic system comprised of a polydimethylsiloxane (PDMS) device cast in customizable 3D printed molds and a printed circuit board (PCB), which employs commercially available engineering components and tools throughout design and fabrication. The system, featuring solution-filled reservoirs, embedded electrodes, and hydrogel-filled capillary tubing, is assembled modularly. The PDMS and PCB both contain matching through-holes designed to hold metallic contact posts coated with silver epoxy, allowing for mechanical and electrical integration. This assembly scheme allows us to interchange subsystem components, such as various PCB designs and reservoir solutions. We present three PCB designs: a wired version and two battery-powered versions with and without onboard memory. The wired design uses an external voltage controller for device actuation. The battery-powered PCB design uses a microcontroller unit to enable pre-programmed applied voltages and deep sleep mode to prolong battery run time. Finally, the battery-powered PCB with onboard memory is developed to record delivered currents, which enables us to verify treatment dose delivered. To demonstrate the functionality of the platform, the devices are used to deliver H + in vivo using mouse models and fluoxetine ex vivo using a simulated wound environment. Immunohistochemistry staining shows an improvement of 35.86% in the M1/M2 ratio of H + —treated wounds compared with control wounds, indicating the potential of the platform to improve wound healing. [ABSTRACT FROM AUTHOR] |
|
Copyright of Scientific Reports is the property of Springer Nature and its content may not be copied or emailed to multiple sites or posted to a listserv without the copyright holder's express written permission. However, users may print, download, or email articles for individual use. This abstract may be abridged. No warranty is given about the accuracy of the copy. Users should refer to the original published version of the material for the full abstract. (Copyright applies to all Abstracts.) |
| قاعدة البيانات: |
Complementary Index |
Full Text Finder